Rapid optimisation of fragments and hits to lead compounds from screening of crude reaction mixtures
Sign Up to like & getrecommendations! Published in 2020 at "Communications Chemistry"
DOI: 10.1038/s42004-020-00367-0
Abstract: Fragment based methods are now widely used to identify starting points in drug discovery and generation of tools for chemical biology. A significant challenge is optimization of these weak binding fragments to hit and lead… read more here.
Keywords: reaction mixtures; rapid optimisation; crude reaction; lead compounds ... See more keywords
Rapid optimisation of cellulolytic enzymes ratios in Saccharomyces cerevisiae using in vitro SCRaMbLE
Sign Up to like & getrecommendations! Published in 2020 at "Biotechnology for Biofuels"
DOI: 10.1186/s13068-020-01823-8
Abstract: Background For the economic production of biofuels and other valuable products from lignocellulosic waste material, a consolidated bioprocessing (CBP) organism is required. With efficient fermentation capability and attractive industrial qualities, Saccharomyces cerevisiae is a preferred… read more here.
Keywords: saccharomyces cerevisiae; vitro scramble; rapid optimisation; cellulolytic enzymes ... See more keywords