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Published in 2018 at "Molecular Neurobiology"
DOI: 10.1007/s12035-018-1143-4
Abstract: Currently available antidepressants have a substantial time lag to induce therapeutic response and a relatively low efficacy. The development of drugs that addresses these limitations is critical to improving public health. Cannabidiol (CBD), a non-psychotomimetic…
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Keywords:
rapid sustained;
like effects;
sustained antidepressant;
antidepressant like ... See more keywords
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Published in 2017 at "Behavioural Brain Research"
DOI: 10.1016/j.bbr.2017.06.010
Abstract: Resolvin D1 (RvD1) and D2 (RvD2) are lipid mediators that are derived from docosahexaenoic acid. We recently demonstrated that intracerebroventricular (i.c.v.) infusions of RvD1 or RvD2 attenuate lipopolysaccharide-induced depression-like behaviors via mammalian target of rapamycin…
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Keywords:
rapid sustained;
unpredictable stress;
chronic unpredictable;
rvd1 rvd2 ... See more keywords
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Published in 2018 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.8b03942
Abstract: Photoswitchable neurotransmitter receptors are powerful tools for precise manipulation of neural signaling. However, their applications for slow or long-lasting biological events are constrained by fast thermal relaxation of cis-azobenzene. We address this issue by modifying…
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Keywords:
tethered ligand;
rapid sustained;
manipulation;
sustained manipulation ... See more keywords
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Published in 2019 at "Ocular Immunology and Inflammation"
DOI: 10.1080/09273948.2017.1351573
Abstract: ABSTRACT Purpose: To evaluate golimumab (GOL) efficacy in the management of Behçet’s disease (BD)-related uveitis. Methods: We retrospectively collected data from 5 patients (8 eyes) with at least two recent relapses of uveitis, treated with…
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Keywords:
rapid sustained;
sustained efficacy;
golimumab;
beh disease ... See more keywords
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Published in 2023 at "Clinical and experimental dermatology"
DOI: 10.1093/ced/llad108
Abstract: Generalized pustular psoriasis (GPP) is a rare skin disease characterized by generalized sterile pustules with or without severe systemic symptoms. Here we share our experience with Spesolimab in 5 Chinese GPP flare patients.
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Keywords:
spesolimab;
sustained response;
generalized pustular;
pustular psoriasis ... See more keywords
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Published in 2023 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2023.988947
Abstract: Introduction Aspergillus fumigatus (Asp) infections constitute a major cause of morbidity and mortality in patients following allogeneic hematopoietic stem cell transplantation (HSCT). In the context of insufficient host immunity, antifungal drugs show only limited efficacy.…
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Keywords:
cell based;
cell;
combined two;
rapid sustained ... See more keywords