Cannabidiol Induces Rapid and Sustained Antidepressant-Like Effects Through Increased BDNF Signaling and Synaptogenesis in the Prefrontal Cortex
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Neurobiology"
DOI: 10.1007/s12035-018-1143-4
Abstract: Currently available antidepressants have a substantial time lag to induce therapeutic response and a relatively low efficacy. The development of drugs that addresses these limitations is critical to improving public health. Cannabidiol (CBD), a non-psychotomimetic… read more here.
Keywords: rapid sustained; like effects; sustained antidepressant; antidepressant like ... See more keywords
Rapid and sustained antidepressant effects of resolvin D1 and D2 in a chronic unpredictable stress model
Sign Up to like & getrecommendations! Published in 2017 at "Behavioural Brain Research"
DOI: 10.1016/j.bbr.2017.06.010
Abstract: Resolvin D1 (RvD1) and D2 (RvD2) are lipid mediators that are derived from docosahexaenoic acid. We recently demonstrated that intracerebroventricular (i.c.v.) infusions of RvD1 or RvD2 attenuate lipopolysaccharide-induced depression-like behaviors via mammalian target of rapamycin… read more here.
Keywords: rapid sustained; unpredictable stress; chronic unpredictable; rvd1 rvd2 ... See more keywords
Design of a Highly Bistable Photoswitchable Tethered Ligand for Rapid and Sustained Manipulation of Neurotransmission.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.8b03942
Abstract: Photoswitchable neurotransmitter receptors are powerful tools for precise manipulation of neural signaling. However, their applications for slow or long-lasting biological events are constrained by fast thermal relaxation of cis-azobenzene. We address this issue by modifying… read more here.
Keywords: tethered ligand; rapid sustained; manipulation; sustained manipulation ... See more keywords
Rapid and Sustained Efficacy of Golimumab in the Treatment of Multirefractory Uveitis Associated with Behçet’s Disease
Sign Up to like & getrecommendations! Published in 2019 at "Ocular Immunology and Inflammation"
DOI: 10.1080/09273948.2017.1351573
Abstract: ABSTRACT Purpose: To evaluate golimumab (GOL) efficacy in the management of Behçet’s disease (BD)-related uveitis. Methods: We retrospectively collected data from 5 patients (8 eyes) with at least two recent relapses of uveitis, treated with… read more here.
Keywords: rapid sustained; sustained efficacy; golimumab; beh disease ... See more keywords
Rapid and sustained response to Spesolimab in five Chinese patients with generalized pustular psoriasis.
Sign Up to like & getrecommendations! Published in 2023 at "Clinical and experimental dermatology"
DOI: 10.1093/ced/llad108
Abstract: Generalized pustular psoriasis (GPP) is a rare skin disease characterized by generalized sterile pustules with or without severe systemic symptoms. Here we share our experience with Spesolimab in 5 Chinese GPP flare patients. read more here.
Keywords: spesolimab; sustained response; generalized pustular; pustular psoriasis ... See more keywords
Psilocybin promotes neuroplasticity and induces rapid and sustained antidepressant-like effects in mice
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Psychopharmacology"
DOI: 10.1177/02698811241249436
Abstract: Background: Psilocybin offers new hope for treating mood disorders due to its rapid and sustained antidepressant effects, as standard medications require weeks or months to exert their effects. However, the mechanisms underlying this action of… read more here.
Keywords: neuroplasticity; sustained antidepressant; rapid sustained; effects mice ... See more keywords
Rapid and sustained T cell-based immunotherapy against invasive fungal disease via a combined two step procedure
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2023.988947
Abstract: Introduction Aspergillus fumigatus (Asp) infections constitute a major cause of morbidity and mortality in patients following allogeneic hematopoietic stem cell transplantation (HSCT). In the context of insufficient host immunity, antifungal drugs show only limited efficacy.… read more here.
Keywords: cell based; cell; combined two; rapid sustained ... See more keywords
Case report: Dezocine’s rapid and sustained antidepressant effects
Sign Up to like & getrecommendations! Published in 2024 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2024.1411119
Abstract: Anhedonia and motivational impairments are cardinal features of depression, against which conventional antidepressants demonstrate limited efficacy. Preclinical investigations and extant clinical trial data substantiate the promise of opioid receptor modulators in addressing anhedonia, depression, and… read more here.
Keywords: dezocine rapid; dezocine; case report; rapid sustained ... See more keywords