Novel mechanism of endocrine disruption by fungicides through binding to the membrane androgen receptor, ZIP9 (SLC39A9), and antagonizing rapid testosterone induction of the intrinsic apoptotic pathway
Sign Up to like & getrecommendations! Published in 2019 at "Steroids"
DOI: 10.1016/j.steroids.2019.05.007
Abstract: A variety of pesticides including vinclozolin, its metabolite M2 (3',5'-dichloro-2-hydroxy-2-methylbut-3-enanilide), and prochloraz have been shown to exert antiandrogenic effects in animal models by competing with androgen binding to nuclear androgen receptors (nAR) and decreasing transcription… read more here.
Keywords: disruption; androgen; rapid testosterone; zip9 ... See more keywords
Abstract 3227: Getting rid of obesity in middle-to-late adulthood relates to lower prostate cancer risk: Another piece of evidence supporting the “rapid testosterone reduction theory”
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Research"
DOI: 10.1158/1538-7445.am2018-3227
Abstract: Background: Previously we demonstrated that a smoothed age-related decline in testosterone was associated with decreased risk of prostate cancer (PCa) (“rapid testosterone reduction theory”). Obesity relates to low testosterone, so body weight pattern reflecting smoothed… read more here.
Keywords: risk; rapid testosterone; pca; cancer ... See more keywords