Abstract 5992: Cells rapidly adapt to CDK2 inhibitors via plasticity of the CDK2/4/6-Rb-E2F axis
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DOI: 10.1158/1538-7445.am2023-5992
Abstract: CDK2 is a core cell-cycle enzyme that phosphorylates a variety of substrates to drive progression through the cell cycle. CDK2 is hyperactivated in multiple cancers and is therefore an attractive therapeutic target. Here, application of… read more here.
Keywords: cdk2; plasticity; e2f; rapidly adapt ... See more keywords