Characterization of a rarely reported STAT5B/RARA gene fusion in a young adult with newly diagnosed acute promyelocytic leukemia with resistance to ATRA therapy.
Sign Up to like & getrecommendations! Published in 2019 at "Cancer genetics"
DOI: 10.1016/j.cancergen.2019.06.007
Abstract: The detection of PML/RARA or variant RARA rearrangements is critical for the diagnosis and treatment of patients with newly diagnosed acute promyelocytic leukemia (APL). While most cases of APL harboring the PML/RARA fusion respond to… read more here.
Keywords: acute promyelocytic; fusion; diagnosed acute; rara ... See more keywords
Investigating karst collapse geohazards using magnetotellurics: A case study of M'rara basin, Algerian Sahara
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Applied Geophysics"
DOI: 10.1016/j.jappgeo.2018.11.011
Abstract: Abstract The region of M'rara, which is located in the northeast Algerian Sahara basin, is seriously affected by several natural hazards. This region is exposed to risks such as the collapses and fissures around the… read more here.
Keywords: basin; study; rara; algerian sahara ... See more keywords
DNA flap creation by the RarA/MgsA protein of Escherichia coli
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DOI: 10.1093/nar/gkw1322
Abstract: Abstract We identify a novel activity of the RarA (also MgsA) protein of Escherichia coli, demonstrating that this protein functions at DNA ends to generate flaps. A AAA+ ATPase in the clamp loader clade, RarA… read more here.
Keywords: mgsa protein; rara; dna; escherichia coli ... See more keywords
Recurrent RARB Translocations in Acute Promyelocytic Leukemia Lacking RARA Translocation.
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DOI: 10.1158/0008-5472.can-18-0840
Abstract: Translocations of retinoic acid receptor-α (RARA), typically PML-RARA, are a genetic hallmark of acute promyelocytic leukemia (APL). However, because a small fraction of APL lack translocations of RARA, we focused here on APL cases without… read more here.
Keywords: acute promyelocytic; rara; rarb; promyelocytic leukemia ... See more keywords
Abstract P6-11-18: A novel subgroup of estrogen receptor positive breast cancer may benefit from super-enhancer guided patient selection for retinoic acid receptor α agonist treatment
Sign Up to like & getrecommendations! Published in 2017 at "Cancer Research"
DOI: 10.1158/1538-7445.sabcs16-p6-11-18
Abstract: Endocrine-resistance remains a major challenge for treatment of breast cancer. Multiple mechanisms for endocrine resistance have been proposed, including altered expression of ER co-regulators such as Retinoic Acid Receptor Alpha (RARα). Furthermore, crosstalk between estradiol… read more here.
Keywords: rara; treatment; breast cancer; cancer ... See more keywords
An Atypical PML-RARA Rearrangement Resulting from Submicroscopic Insertion of the RARA Gene at the PML Locus with Novel Breakpoints within PML Exon 7b and RARA Exon 3
Sign Up to like & getrecommendations! Published in 2019 at "Acta Haematologica"
DOI: 10.1159/000498842
Abstract: The diagnostic hallmark of acute promyelocytic leukemia (APL) is the reciprocal translocation t(15;17), resulting in the characteristic PML-RARA fusion; however, patients occasionally have masked PML-RARArearrangements. We report an APL case with no evidence of t(15;17)… read more here.
Keywords: rara; novel breakpoints; within pml; pml rara ... See more keywords
FNDC3B is another novel partner fused to RARA in the t(3;17)(q26;q21) variant of acute promyelocytic leukemia.
Sign Up to like & getrecommendations! Published in 2017 at "Blood"
DOI: 10.1182/blood-2017-02-767707
Abstract: To the editor: Acute promyelocytic leukemia (APL) is characterized by the promyelocytic leukemia-retinoic acid receptor α ( PML-RARA ) fusion. In rare instances, RARA is fused to other partners, which dictate sensitivity to targeted therapies.… read more here.
Keywords: acute promyelocytic; rara; promyelocytic leukemia; another novel ... See more keywords
Successful treatment and integrated genomic analysis of an infant with FIP1L1-RARA fusion-associated myeloid neoplasm.
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DOI: 10.1182/bloodadvances.2021004966
Abstract: FIP1L1-RARA associated neoplasm is a very rare and aggressive disease, with only 3 previously reported cases in the literature. Herein we describe a 9-month-old boy who presented with a FIP1L1-RARA fusion associated myelodysplastic/myeloproliferative (MDS/MPN) neoplasm-like… read more here.
Keywords: rara fusion; fip1l1 rara; rara; fusion associated ... See more keywords
RNF8 is responsible for ATRA resistance in variant acute promyelocytic leukemia with GTF2I/RARA fusion, and inhibition of the ubiquitin–proteasome pathway contributes to the reversion of ATRA resistance
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DOI: 10.1186/s12935-019-0803-4
Abstract: BackgroundGTF2I-RARA is a newly identified RARA fusion gene in variant acute promyelocytic leukemia (APL) patients with t(7;17)(q11;q21). Clinical manifestation in the patient showed that it is a sort of ATRA-insensitive oncogene and is different from… read more here.
Keywords: gtf2i rara; atra resistance; rara fusion; rara ... See more keywords
Current views on the genetic landscape and management of variant acute promyelocytic leukemia
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DOI: 10.1186/s40364-021-00284-x
Abstract: Acute promyelocytic leukemia (APL) is characterized by the accumulation of promyelocytes in bone marrow. More than 95% of patients with this disease belong to typical APL, which express PML-RARA and are sensitive to differentiation induction… read more here.
Keywords: apl; variant apl; genetic landscape; rara ... See more keywords
Acute promyelocytic leukemia with FIP1L1::RARA fusion gene: The clinical utility of transcriptome sequencing and bioinformatic analyses
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.1049473
Abstract: Background Acute promyelocytic leukemia (APL) is typically characterized by the presence of coagulopathy and the PML::RARA fusion gene. The FIP1L1::RARA has been reported as a novel fusion gene, but studies on its pathogenesis are limited.… read more here.
Keywords: rara; fip1l1 rara; rara fusion; signaling pathway ... See more keywords