DNA methylation is not involved in specific down-regulation of HSD3B2, NR4A1 and RARB genes in androgen-secreting cells of human adrenal cortex
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DOI: 10.1016/j.mce.2016.09.024
Abstract: We hypothesized that DNA methylation is involved in human adrenal functional zonation. mRNAs expression and methylation pattern of RARB, NR4A1 and HSD3B2 genes in human adrenal tissues (HAT) and in pediatric virilizing adrenocortical tumors (VAT)… read more here.
Keywords: methylation; human adrenal; rarb; hsd3b2 ... See more keywords
Deleted in lymphocytic leukemia 2 induces retinoic acid receptor beta promoter methylation and mitogen activated kinase-like protein activation to enhance viability and mobility of colorectal cancer cells
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DOI: 10.1080/21655979.2022.2076482
Abstract: ABSTRACT Abnormal expression of long non-coding RNAs (lncRNAs) is frequently linked to the pathogenesis of colorectal cancer (CRC). This work explored the function of lncRNA deleted in lymphocytic leukemia 2 (DLEU2) in CRC and the… read more here.
Keywords: crc; rarb; promoter methylation; viability ... See more keywords
Epigenetic regulation of RARB overcomes the radio-resistance of colorectal carcinoma cells via cancer stem cells
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DOI: 10.1093/jrr/rrac060
Abstract: Abstract Cancer stem cells (CSCs) are able to survive after cancer therapies, leading to cancer progression and recurrence in colorectal carcinoma (CRC). Therapies targeting CSCs are believed to be promising strategies for efficiently eradicating cancers.… read more here.
Keywords: radio resistance; cancer stem; colorectal carcinoma; stem cells ... See more keywords
Recurrent RARB Translocations in Acute Promyelocytic Leukemia Lacking RARA Translocation.
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DOI: 10.1158/0008-5472.can-18-0840
Abstract: Translocations of retinoic acid receptor-α (RARA), typically PML-RARA, are a genetic hallmark of acute promyelocytic leukemia (APL). However, because a small fraction of APL lack translocations of RARA, we focused here on APL cases without… read more here.
Keywords: acute promyelocytic; rara; rarb; promyelocytic leukemia ... See more keywords