Twist1 sustains the apoptosis resistance in eosinophils in nasal mucosa of allergic rhinitis.
Sign Up to like & getrecommendations! Published in 2021 at "Archives of biochemistry and biophysics"
DOI: 10.1016/j.abb.2021.108828
Abstract: Eosinophils (Eos) are the canonical effector cells in allergic rhinitis (AR) and many inflammatory diseases. The mechanism of eosinophilia occurring in the lesion sites is not fully understood yet. Twist1 protein (Twist, in short) is… read more here.
Keywords: apoptosis resistance; ras activation; activation; eos ... See more keywords
Abstract CN05-02: Next generation strategies to overcome adaptive resistance to MAPK-directed therapies
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Cancer Therapeutics"
DOI: 10.1158/1535-7163.targ-19-cn05-02
Abstract: Adaptive resistance remains a major challenge limiting the clinical effectiveness of inhibitors of oncogenic MAPK signaling (RAF and MEK inhibitors), there is thus a pressing need for compounds and combinatorial strategies that would potently and… read more here.
Keywords: overcome adaptive; resistance; ras activation; adaptive resistance ... See more keywords
Abstract 4364: R-Ras activation cooperates with BRAF mutation in melanoma tumorigenesis
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Research"
DOI: 10.1158/1538-7445.am2018-4364
Abstract: The Ras family of small GTP binding proteins are tightly regulated through a complex network of proteins. In melanoma the Ras signaling pathway is frequently activated by mutations in NRAS (20%), KRAS (2%) and HRAS… read more here.
Keywords: melanoma; activation cooperates; ras activation; activation ... See more keywords