Analysis of patient-specific NF1 variants leads to functional insights for Ras signaling that can impact personalized medicine.
Sign Up to like & getrecommendations! Published in 2021 at "Human mutation"
DOI: 10.1002/humu.24290
Abstract: We have created a panel of twenty-nine NF1 variant cDNAs representing missense (MS) variants, many with clinically relevant phenotypes, in-frame deletions, splice variants, and nonsense (NS) variants. We have determined the functional consequences of the… read more here.
Keywords: ras activity; medicine; patient specific; analysis patient ... See more keywords
Noninvasive Imaging of Ras Activity by Monomolecular Biosensor Based on Split-Luciferase Complementary Assay
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DOI: 10.1038/s41598-017-08358-3
Abstract: Deregulated activity of Ras GTPases has been observed in many types of human cancers, and contributes to the diverse aspects of carcinogenesis. Although the significance in tumorigenesis has been widely accepted and many therapeutic drugs… read more here.
Keywords: ras activity; based split; biosensor; luciferase ... See more keywords
Abstract 2238: RAS activity-related features of metastatic pancreatic cancer
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-2238
Abstract: Background: RAS activity might play crucial roles in the aggravation of KRAS-mutated pancreatic cancer (PC), including systemic inflammatory reactions, tumor-driven inflammation, chemo-refractoriness and anorexia. We aimed to identify RAS activity-related features in PC patients with… read more here.
Keywords: related features; ras activity; activity related; pancreatic cancer ... See more keywords
Abstract B015: Wildtype RAS activity and PI3K signaling as new vulnerabilities in cells with acquired resistance to sotorasib
Sign Up to like & getrecommendations! Published in 2023 at "Molecular Cancer Research"
DOI: 10.1158/1557-3125.ras23-b015
Abstract: Purpose: Sotorasib (AMG510) has demonstrated remarkable response in lung cancer patients with tumors driven by oncogenic KRASG12C mutation. However, recently published clinical data identified acquired mutations in RAS and other genomic alterations as potential mechanisms… read more here.
Keywords: ras activity; lu65 amgr; resistance; pi3k signaling ... See more keywords
Blocking K-Ras Interaction With the Plasma Membrane Is a Tractable Therapeutic Approach to Inhibit Oncogenic K-Ras Activity
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Molecular Biosciences"
DOI: 10.3389/fmolb.2021.673096
Abstract: Ras proteins are membrane-bound small GTPases that promote cell proliferation, differentiation, and apoptosis. Consistent with this key regulatory role, activating mutations of Ras are present in ∼19% of new cancer cases in the United States… read more here.
Keywords: ras activity; ras; oncogenic ras; ras driven ... See more keywords