R-Ras-Akt axis induces endothelial lumenogenesis and regulates the patency of regenerating vasculature
Sign Up to like & getrecommendations! Published in 2017 at "Nature Communications"
DOI: 10.1038/s41467-017-01865-x
Abstract: The formation of endothelial lumen is fundamental to angiogenesis and essential to the oxygenation of hypoxic tissues. The molecular mechanism underlying this important process remains obscure. Here, we show that Akt activation by a Ras… read more here.
Keywords: akt axis; lumenogenesis; endothelial lumenogenesis; patency regenerating ... See more keywords
Di2-ethylhexyl phthalate disrupts thyroid hormone homeostasis through activating the Ras/Akt/TRHr pathway and inducing hepatic enzymes
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/srep40153
Abstract: Di(2-ethylhexyl) phthalate (DEHP), as a widespread environmental pollutant and an endocrine disruptor, can disturb the homeostasis of thyroid hormones (THs). In order to elucidate roles of the MAPK and PI3K/Akt pathways and hepatic enzymes in… read more here.
Keywords: homeostasis; trhr pathway; hepatic enzymes; akt trhr ... See more keywords