Biophysical and structural characterization of novel RAS-binding domains (RBDs) of PI3Kα and PI3Kγ.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of molecular biology"
DOI: 10.1016/j.jmb.2021.166838
Abstract: Phosphatidylinositol-3-kinases (PI3Ks) are lipid kinases that phosphorylate phosphatidylinositol 4,5-bisphosphate to generate a key lipid second messenger, phosphatidylinositol 3,4,5-bisphosphate. PI3Kα and PI3Kγ require activation by RAS proteins to stimulate signaling pathways that control cellular growth, differentiation,… read more here.
Keywords: pi3k; ras binding; binding domains; pi3k pi3k ... See more keywords
Structure-based development of new RAS-effector inhibitors from a combination of active and inactive RAS-binding compounds
Sign Up to like & getrecommendations! Published in 2019 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.1811360116
Abstract: Significance The RAS family of oncogenic proteins is important as therapy targets because of the frequency of activating mutations in almost all major cancers. An important approach is development of small molecules with drug-like properties… read more here.
Keywords: ras binding; ras effector; protein protein; structure based ... See more keywords