The membrane-associated protein 17 (MAP17) is up-regulated in response to empagliflozin on top of RAS blockade in experimental diabetic nephropathy.
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DOI: 10.1042/cs20220447
Abstract: Sodium-glucose cotransporter 2 inhibitors (SGLT2i) have proven to delay diabetic kidney disease (DKD) progression on top of the standard of care with the renin-angiotensin system (RAS) blockade. The molecular mechanisms underlying the synergistic effect of… read more here.
Keywords: top ras; empagliflozin; map17 regulated; ras blockade ... See more keywords
Renin–angiotensin system blockade alone or combined with ETA receptor blockade: effects on the course of chronic kidney disease in 5/6 nephrectomized Ren-2 transgenic hypertensive rats
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DOI: 10.1080/10641963.2016.1235184
Abstract: ABSTRACT Background: Early addition of endothelin (ET) type A (ETA) receptor blockade to complex renin–angiotensin system (RAS) blockade has previously been shown to provide better renoprotection against progression of chronic kidney disease (CKD) in Ren-2… read more here.
Keywords: blockade alone; receptor blockade; blockade; receptor ... See more keywords
SP269BLOOD TESTS DURING PREGNANCYTHAT MAY PREDICT LONG-TERM CARDIOVASCULAR MORBIDITY
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DOI: 10.1093/ndt/gfy104.sp269
Abstract: METHODS: Retrospective, observational study in an incident cohort of adult patients with CKD stage 4 or 5 not on dialysis, treated with RAS blockers for at least 6 months prior to the study inclusion. Inclusion… read more here.
Keywords: renal function; dual ras; end ras; ras blockade ... See more keywords
A5743 Blood Pressure Effects of Systemic or Central Angiotensin II in Hypertensive Ren-2 Transgenic Rats: Sympathoinhibition Induced by Central RAS Blockade
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DOI: 10.1097/01.hjh.0000548156.06822.af
Abstract: Objectives: Chronic blockade of renin-angiotensin system (RAS) lowered blood pressure (BP) in Ren-2 transgenic rats (TGR) by attenuation of both angiotensin II-dependent and sympathetic vasoconstriction. The aim of our study was to determine whether central… read more here.
Keywords: blood pressure; central ras; systemic central; ren transgenic ... See more keywords
A17284 The modulation of angiotensin peptide levels by RAS blockade in spontaneously hypertensive rats
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DOI: 10.1097/01.hjh.0000548350.11218.8f
Abstract: Objectives: There are only sparse data on dual (or single) RAS blockade effect on angiotensin peptides. We aimed to investigate the effects of single/combined RAS blockade on angiotensin peptides in spontaneously hypertensive rats (SHR). Methods:… read more here.
Keywords: spontaneously hypertensive; hypertensive rats; blockade; peptide levels ... See more keywords
Mineralocorticoid Receptor Antagonists for Nephroprotection: Current Evidence and Future Perspectives.
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DOI: 10.2174/1381612825666190306162658
Abstract: BACKGROUND The use of single RAS-blockade is currently the recommended first-line treatment for proteinuric diabetic or non-diabetic nephropathy, as these agents were repeatedly shown in studies with hard renal outcomes to retard the progression of… read more here.
Keywords: renal outcomes; mineralocorticoid receptor; diabetic nephropathy; receptor antagonists ... See more keywords