HMGB1‐RAGE signaling facilitates Ras‐dependent Yap1 expression to drive colorectal cancer stemness and development
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Carcinogenesis"
DOI: 10.1002/mc.22944
Abstract: HMGB1‐RAGE signaling plays an integral role in inflammation‐driven carcinogenesis. In the present study, we showed that RAGE has direct association with K‐Ras following HMGB1 exposure in colorectal cancer (CRC) cells. Immunofluorescence analysis revealed a significant… read more here.
Keywords: hmgb1 rage; ras dependent; expression; rage ... See more keywords
Stimulation of RAS-dependent ROS signaling extends longevity by modulating a developmental program of global gene expression
Sign Up to like & getrecommendations! Published in 2022 at "Science Advances"
DOI: 10.1126/sciadv.adc9851
Abstract: We show that elevation of mitochondrial superoxide generation increases Caenorhabditis elegans life span by enhancing a RAS-dependent ROS (reactive oxygen species) signaling pathway (RDRS) that controls the expression of half of the genome as well… read more here.
Keywords: superoxide; ras dependent; dependent ros; program ... See more keywords
Abstract A026: Stochastic phenotypes in RAS-dependent developmental diseases
Sign Up to like & getrecommendations! Published in 2023 at "Molecular Cancer Research"
DOI: 10.1158/1557-3125.ras23-a026
Abstract: Germline mutations upregulating RAS signaling are associated with multiple developmental disorders. A hallmark of these conditions is that the same mutation may present vastly different phenotypes in different individuals, even in monozygotic twins. We demonstrate… read more here.
Keywords: dependent developmental; phenotypes ras; ras dependent; stochastic phenotypes ... See more keywords