Synthetic Lethal Interaction of SHOC2 Depletion with MEK Inhibition in RAS-Driven Cancers.
Sign Up to like & getrecommendations! Published in 2019 at "Cell reports"
DOI: 10.1016/j.celrep.2019.08.090
Abstract: The mitogen-activated protein kinase (MAPK) pathway is a critical effector of oncogenic RAS signaling, and MAPK pathway inhibition may be an effective combination treatment strategy. We performed genome-scale loss-of-function CRISPR-Cas9 screens in the presence of… read more here.
Keywords: mek inhibition; inhibition; depletion; ras driven ... See more keywords
Photodynamic therapy for ras-driven cancers: targeting G-quadruplex RNA structures with bifunctional alkyl-modified porphyrins.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.9b01577
Abstract: Designing small molecules capable to break down G4 structures in mRNA (RG4s) offers an interesting approach to cancer therapy. Here, we have studied cationic porphyrins (CPs) bearing an alkyl chain up to 12 carbons, as… read more here.
Keywords: photodynamic therapy; alkyl cps; therapy; therapy ras ... See more keywords
Protective autophagy elicited by RAF→MEK→ERK inhibition suggests a treatment strategy for RAS-driven cancers
Sign Up to like & getrecommendations! Published in 2019 at "Nature medicine"
DOI: 10.1038/s41591-019-0367-9
Abstract: Pancreatic ductal adenocarcinoma (PDA) was responsible for ~ 44,000 deaths in the United States in 2018 and is the epitome of a recalcitrant cancer driven by a pharmacologically intractable oncoprotein, KRAS1–4. Downstream of KRAS, the RAF→MEK→ERK… read more here.
Keywords: mek erk; inhibition; driven cancers; ras driven ... See more keywords
ONECUT2 overexpression promotes RAS-driven lung adenocarcinoma progression
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-56277-2
Abstract: Aberrant differentiation, driven by activation of normally silent tissue-specific genes, results in a switch of cell identity and often leads to cancer progression. The underlying genetic and epigenetic events are largely unexplored. Here, we report… read more here.
Keywords: lung adenocarcinoma; driven lung; onecut2 overexpression; cancer ... See more keywords
ATOH8 binds SMAD3 to induce cellular senescence and prevent Ras-driven malignant transformation.
Sign Up to like & getrecommendations! Published in 2023 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2208927120
Abstract: The process of oncogene-induced senescence (OIS) and the conversion between OIS and malignant transformation during carcinogenesis is poorly understood. Here, we show that following overactivation of oncogene Ras in lung epithelial cells, high-level transforming growth… read more here.
Keywords: ras driven; senescence; driven malignant; cellular senescence ... See more keywords
Abstract B17: MEK inhibition induces myogenic differentiation in RAS-driven rhabdomyosarcoma
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Cancer Research"
DOI: 10.1158/1557-3125.ras18-b17
Abstract: Fusion-negative rhabdomyosarcoma (FN-RMS), which lacks PAX3/7 gene rearrangement, arises from skeletal muscle precursor cells that fail to differentiate despite expression of the myogenic master transcription factor, MYOD1. These tumors frequently harbor mutations in RAS isoforms… read more here.
Keywords: ras driven; differentiation; myogenic differentiation; mek inhibition ... See more keywords
A genome-wide Drosophila epithelial tumorigenesis screen identifies Tetraspanin 29Fb as an evolutionarily conserved suppressor of Ras-driven cancer
Sign Up to like & getrecommendations! Published in 2018 at "PLoS Genetics"
DOI: 10.1371/journal.pgen.1007688
Abstract: Oncogenic mutations in the small GTPase Ras contribute to ~30% of human cancers. However, Ras mutations alone are insufficient for tumorigenesis, therefore it is paramount to identify cooperating cancer-relevant signaling pathways. We devised an in… read more here.
Keywords: drosophila; tumorigenesis; evolutionarily conserved; screen ... See more keywords
BR2 cell penetrating peptide effectively delivers anti-p21Ras scFv to tumor cells with ganglioside expression for therapy of ras-driven tumor
Sign Up to like & getrecommendations! Published in 2022 at "PLoS ONE"
DOI: 10.1371/journal.pone.0269084
Abstract: Purpose Cell membrane penetrating peptide BR2 can bind with ganglioside and introduce foreign drugs into tumor cells. In this study, we employed BR2 to carry the broad-spectrum anti-p21Ras scFv prepared in our laboratory into ganglioside… read more here.
Keywords: cell; ras driven; tumor cells; fusion protein ... See more keywords
Blocking K-Ras Interaction With the Plasma Membrane Is a Tractable Therapeutic Approach to Inhibit Oncogenic K-Ras Activity
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Molecular Biosciences"
DOI: 10.3389/fmolb.2021.673096
Abstract: Ras proteins are membrane-bound small GTPases that promote cell proliferation, differentiation, and apoptosis. Consistent with this key regulatory role, activating mutations of Ras are present in ∼19% of new cancer cases in the United States… read more here.
Keywords: ras activity; ras; oncogenic ras; ras driven ... See more keywords
Ferroptosis: A Specific Vulnerability of RAS-Driven Cancers?
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.923915
Abstract: Ferroptosis has emerged as a new type of programmed cell death that can be harnessed for cancer therapy. The concept of ferroptosis was for the first time proposed in in the early 2000s, as an… read more here.
Keywords: ras driven; ferroptosis specific; specific vulnerability; vulnerability ras ... See more keywords