Ras–ERK1/2 signaling promotes the development of uveal melanoma by downregulating H3K14ac
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.28259
Abstract: Ras–extracellular signal‐regulated protein kinases 1 and 2 (ERK1/2) signaling has been proposed as the crucial regulators in the development of various cancers. Histone acetylation at H3 lysine 14 (H3K14ac) is closely associated with gene expression… read more here.
Keywords: uveal melanoma; expression; cell; ras erk1 ... See more keywords
Ras-ERK1/2 signaling contributes to the development of colorectal cancer via regulating H3K9ac
Sign Up to like & getrecommendations! Published in 2018 at "BMC Cancer"
DOI: 10.1186/s12885-018-5199-3
Abstract: Backgrounds/aimsRas is a control switch of ERK1/2 pathway, and hyperactivation of Ras-ERK1/2 signaling appears frequently in human cancers. However, the molecular regulation following by Ras-ERK1/2 activation is still unclear. This work aimed to reveal whether… read more here.
Keywords: development colorectal; colorectal cancer; h3k9ac; erk1 signaling ... See more keywords
Tspan9 Induces EMT and Promotes Osteosarcoma Metastasis via Activating FAK-Ras-ERK1/2 Pathway
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.774988
Abstract: Object At present, there are few effective treatment options available to patients suffering from osteosarcoma (OS). Clarifying the signaling pathways that govern OS oncogenesis may highlight novel approaches to treating this deadly form of cancer.… read more here.
Keywords: metastasis via; fak ras; tspan9 induces; metastasis ... See more keywords