RAS GTPase signalling to alternative effector pathways.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical Society transactions"
DOI: 10.1042/bst20200506
Abstract: RAS GTPases are fundamental regulators of development and drivers of an extraordinary number of human cancers. RAS oncoproteins constitutively signal through downstream effector proteins, triggering cancer initiation, progression and metastasis. In the absence of targeted… read more here.
Keywords: alternative effector; signalling alternative; gtpase signalling; gtpase ... See more keywords
Abstract PR05: The role of the RAS GTPase RIT1 in RASopathies and cancer
Sign Up to like & getrecommendations! Published in 2023 at "Molecular Cancer Research"
DOI: 10.1158/1557-3125.ras23-pr05
Abstract: RAS oncoproteins are drivers of tumor initiation and progression and therapies targeting these directly or their downstream pathways have resulted in unprecedented clinical benefit in cancer. However, recent advances in genomic medicine have revealed that… read more here.
Keywords: ras gtpase; cancer; role; rit1 rasopathies ... See more keywords
Complement Receptor 3-Mediated Inhibition of Inflammasome Priming by Ras GTPase-Activating Protein During Francisella tularensis Phagocytosis by Human Mononuclear Phagocytes
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2018.00561
Abstract: Francisella tularensis is a remarkably infectious facultative intracellular bacterium of macrophages that causes tularemia. Early evasion of host immune responses contributes to the success of F. tularensis as a pathogen. F. tularensis entry into human… read more here.
Keywords: tularensis; cr3; complement receptor; ras gtpase ... See more keywords
Ras GTPase-activating proteins control neuronal circuit development in barrel cortex layer 4
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Neuroscience"
DOI: 10.3389/fnins.2022.901774
Abstract: The cerebral cortex comprises a complex and exquisite network of neuronal circuits that is formed during development. To explore the molecular mechanisms involved in cortical circuit formation, the tactile somatosensory pathway that connects the whiskers… read more here.
Keywords: ras gtpase; activating proteins; circuit; gtpase activating ... See more keywords