Effect of renin-angiotensin system inhibitors on mortality in heart failure with preserved ejection fraction: a meta-analysis of observational cohort and randomized controlled studies
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DOI: 10.1007/s10741-017-9637-0
Abstract: Despite the high mortality rate, there is no therapy to improve survival in heart failure with preserved ejection fraction (HFpEF). Large randomized controlled trials (RCTs) did not show clear mortality benefit of renin-angiotensin system (RAS)… read more here.
Keywords: analysis; mortality; heart failure; ras inhibitors ... See more keywords
EFFECT OF HYPERTENSION AND RAS INHIBITORS TO ADULT PATIENTS (OVER 18 YEARS OLD) WITH SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 (SARS-COV2) INFECTION WHO WERE ADMITTED TO HOSPital
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DOI: 10.1097/01.hjh.0000837264.58736.74
Abstract: Objective: A meta-analysis published in March 2021 concluded that neither the ACE inhibitor nor ARB treatment came together with a higher COVID-19 mortality rate. Our aim was to assess the prevalence of treated HT, the… read more here.
Keywords: ras inhibitors; rate; mortality rate; rate patients ... See more keywords
Can Renin-Angiotensin System Inhibitors Protect Against Acute Kidney Injury in Patients With COVID-19?
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DOI: 10.1097/ccm.0000000000005618
Abstract: Copyright © 2022 by the Society of Critical Care Medicine and Wolters Kluwer Health, Inc. All Rights Reserved. e796 www.ccmjournal.org November 2022 • Volume 50 • Number 11 DOI: 10.1097/CCM.0000000000005618 Copyright © 2022 by the… read more here.
Keywords: ras inhibitors; medicine; acute kidney; kidney injury ... See more keywords
Guideline-directed medical therapy in elderly patients with heart failure with reduced ejection fraction: a cohort study
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DOI: 10.1136/bmjopen-2019-030514
Abstract: Objectives and design Guideline-directed medical therapy (GDMT) with renin–angiotensin system (RAS) inhibitors and beta-blockers has improved survival in patients with heart failure with reduced ejection fraction (HFrEF). As clinical trials usually do not include very… read more here.
Keywords: elderly patients; beta blockers; heart failure; ras inhibitors ... See more keywords
Abstract 6374: Novel RAS inhibitors
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DOI: 10.1158/1538-7445.am2020-6374
Abstract: The Ras oncoprotein may participate in driving half of human tumors and as such remains the single most significant therapeutic target in cancer. Attempts to develop targeted inhibitors of RAS have proved extremely challenging. We… read more here.
Keywords: 6374 novel; inhibitors abstract; novel ras; cancer ... See more keywords
Abstract 6755: The impact of renin-angiotensin system inhibitors on survival outcomes of pancreatic adenocarcinoma patients
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DOI: 10.1158/1538-7445.am2023-6755
Abstract: Introduction Pancreatic adenocarcinoma (PDAC) is a highly aggressive malignancy with significant morbidity and mortality. RAS (renin-angiotensin system) inhibitors have been used for hypertension, and the potential role of using RAS inhibitors in pancreatic adenocarcinoma have… read more here.
Keywords: ras inhibitors; angiotensin system; pancreatic adenocarcinoma; renin angiotensin ... See more keywords
Abstract B018: The development of macrocyclic peptide Ras inhibitors
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DOI: 10.1158/1557-3125.ras23-b018
Abstract: While there has been tremendous progress developing small molecule covalent K-Ras G12C inhibitors that bind Ras-off (GDP) and inhibit nucleotide exchange, there remains a need for additional K-Ras inhibitors with different Ras isoform/mutant selectivity profiles… read more here.
Keywords: ras inhibitors; peptide; macrocyclic peptide; ras ... See more keywords
Discontinuation of Renin-Angiotensin System Inhibitors and Clinical Outcomes in Chronic Kidney Disease: A Systemic Review and Meta-Analysis.
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DOI: 10.1159/000531000
Abstract: BACKGROUND Discontinuation of renin-angiotensin system (RAS) inhibitors is common in patients with chronic kidney disease (CKD) and the potential danger has been reported in several studies. However, a comprehensive analysis has not been conducted. OBJECTIVES… read more here.
Keywords: discontinuation; analysis; ras inhibitors; kidney disease ... See more keywords
Antihypertensive Drug Combinations Modify Cisplatin-induced Acute Kidney Injury
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DOI: 10.21873/invivo.12843
Abstract: Background/Aim: There is limited evidence about the nephrotoxicity of calcium channel blockers (CCBs) and renin-angiotensin system (RAS) inhibitors with concomitant cisplatin (CDDP). We investigated whether combinations of antihypertensive drugs are associated with CDDP-related acute kidney… read more here.
Keywords: ras inhibitors; acute kidney; kidney injury; cisplatin ... See more keywords
In advanced progressive CKD, discontinuing RAS inhibitors did not improve eGFR at 3 y
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DOI: 10.7326/j23-0001
Abstract: SOURCE CITATION Bhandari S, Mehta S, Khwaja A, et al. Renin-angiotensin system inhibition in advanced chronic kidney disease. N Engl J Med. 2022;387:2021-32. 36326117. read more here.
Keywords: advanced progressive; ras inhibitors; inhibitors improve; discontinuing ras ... See more keywords