The K-Ras, N-Ras, and H-Ras Isoforms: Unique Conformational Preferences and Implications for Targeting Oncogenic Mutants.
Sign Up to like & getrecommendations! Published in 2018 at "Cold Spring Harbor perspectives in medicine"
DOI: 10.1101/cshperspect.a031427
Abstract: Ras controls a multitude of cellular signaling processes, including cell proliferation, differentiation, and apoptosis. Deregulation of Ras cycling often promotes tumorigenesis and various other developmental disorders, termed RASopothies. Although the structure of Ras has been… read more here.
Keywords: preferences implications; conformational preferences; ras ras; isoforms unique ... See more keywords
Oncogenic Ras Isoforms Signaling Specificity at the Membrane.
Sign Up to like & getrecommendations! Published in 2018 at "Cancer research"
DOI: 10.1158/0008-5472.can-17-2727
Abstract: How do Ras isoforms attain oncogenic specificity at the membrane? Oncogenic KRas, HRas, and NRas (K-Ras, H-Ras, and N-Ras) differentially populate distinct cancers. How they selectively activate effectors and why is KRas4B the most prevalent… read more here.
Keywords: oncogenic ras; specificity membrane; membrane; ras isoforms ... See more keywords