Somatic RIT1 delins in arteriovenous malformations hyperactivate RAS-MAPK signaling amenable to MEK inhibition
Sign Up to like & getrecommendations! Published in 2024 at "Angiogenesis"
DOI: 10.1007/s10456-024-09934-8
Abstract: Arteriovenous malformations (AVM) are benign vascular anomalies prone to pain, bleeding, and progressive growth. AVM are mainly caused by mosaic pathogenic variants of the RAS-MAPK pathway. However, a causative variant is not identified in all… read more here.
Keywords: arteriovenous malformations; mapk signaling; ras mapk; somatic rit1 ... See more keywords
O19 Ganoderma triterpenes inhibit kidney cyst development via down-regulating the Ras/MAPK signaling pathway
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical Pharmacology"
DOI: 10.1016/j.bcp.2017.06.084
Abstract: Autosomal dominant polycystic kidney disease (ADPKD) is a common monogenetic disease characterized by progressive development of renal cysts that leads to end stage renal disease. The aim of this study was to investigate the effect… read more here.
Keywords: cyst; ras mapk; ganoderma triterpenes; development ... See more keywords
Activation of RAS/MAPK pathway confers MCL-1 mediated acquired resistance to BCL-2 inhibitor venetoclax in acute myeloid leukemia
Sign Up to like & getrecommendations! Published in 2022 at "Signal Transduction and Targeted Therapy"
DOI: 10.1038/s41392-021-00870-3
Abstract: Despite high initial response rates, acute myeloid leukemia (AML) treated with the BCL-2–selective inhibitor venetoclax (VEN) alone or in combinations commonly acquires resistance. We performed gene/protein expression, metabolomic and methylation analyses of isogenic AML cell… read more here.
Keywords: acute myeloid; activation; resistance; myeloid leukemia ... See more keywords
Dominant Noonan syndrome-causing LZTR1 mutations specifically affect the Kelch domain substrate-recognition surface and enhance RAS-MAPK signaling
Sign Up to like & getrecommendations! Published in 2019 at "Human Molecular Genetics"
DOI: 10.1093/hmg/ddy412
Abstract: Noonan syndrome (NS), the most common RASopathy, is caused by mutations affecting signaling through RAS and the MAPK cascade. Recently, genome scanning has discovered novel genes implicated in NS, whose function in RAS-MAPK signaling remains… read more here.
Keywords: kelch domain; noonan syndrome; lztr1 mutations; mapk signaling ... See more keywords
Selfish mutations dysregulating RAS-MAPK signaling are pervasive in aged human testes.
Sign Up to like & getrecommendations! Published in 2018 at "Genome research"
DOI: 10.1101/gr.239186.118
Abstract: Mosaic mutations present in the germline have important implications for reproductive risk and disease transmission. We previously demonstrated a phenomenon occurring in the male germline, whereby specific mutations arising spontaneously in stem cells (spermatogonia) lead… read more here.
Keywords: mutations dysregulating; dysregulating ras; selfish mutations; selection ... See more keywords
Copy number variants of Ras/MAPK pathway genes in patients with isolated cryptorchidism
Sign Up to like & getrecommendations! Published in 2017 at "Andrology"
DOI: 10.1111/andr.12390
Abstract: Cryptorchidism is the most common congenital disorder in boys, but the cause for most cases remains unknown. Patients with Noonan Syndrome are characterized by a typical face, growth retardation, congenital heart defects, learning disabilities and… read more here.
Keywords: cryptorchidism; copy number; isolated cryptorchidism; mapk pathway ... See more keywords
The TAZ-CAMTA1 Fusion Protein Promotes Tumorigenesis via Connective Tissue Growth Factor and Ras–MAPK Signaling in Epithelioid Hemangioendothelioma
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DOI: 10.1158/1078-0432.ccr-22-0421
Abstract: Abstract Purpose: A consistent genetic alteration in vascular cancer epithelioid hemangioendothelioma (EHE) is the t(1;3)(p36;q25) chromosomal translocation, which generates a WWTR1(TAZ)-CAMTA1 (TC) fusion gene. TC is a transcriptional coactivator that drives EHE. Here, we aimed… read more here.
Keywords: ras mapk; epithelioid hemangioendothelioma; tumorigenesis; growth ... See more keywords
Abstract 3170: AKT/mTOR pharmacologic inhibition sensitizes RAS/MAPK-activated neuroblastoma cells to MEK1/2 inhibitors
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Research"
DOI: 10.1158/1538-7445.am2018-3170
Abstract: Relapsed neuroblastoma tumors have an increased incidence of activating mutations in the RAS/MAPK pathway. Pre-clinical studies indicate these tumors have an increased sensitivity to inhibitors of the RAS/MAPK pathway but single-agent therapeutic approaches have rarely… read more here.
Keywords: mek1 inhibitors; tram; inhibition; cell ... See more keywords
Abstract 3878: Targeting Hippo-YAP, BRD4 and RAS-MAPK interplay in lung cancer to forestall drug resistance
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-3878
Abstract: Introduction: Identifying parallel survival pathways or compensatory mechanisms that limit the response to targeted therapy is critical to discover effective combinatorial strategies for the treatment of lung cancer and to prevent emergence of drug resistance… read more here.
Keywords: ras mapk; lung cancer; kras mutant; yap ... See more keywords
Abstract 5510: Targeting BET, Hippo-YAP and RAS-MAPK signaling interplay in lung cancer and therapy resistance
Sign Up to like & getrecommendations! Published in 2025 at "Cancer Research"
DOI: 10.1158/1538-7445.am2025-5510
Abstract: Identifying alternate survival pathways or compensatory mechanisms that limit the response to targeted therapy is critical to discover effective combinatorial strategies for lung cancer treatment and prevention of drug resistance.Using a combinatorial drug screen in… read more here.
Keywords: cancer; resistance; bet; lung cancer ... See more keywords
Abstract A020: CETSA profiling unveils novel targets engaged by anti-tumor drug rigosertib to inhibit RAS-MAPK signaling and trigger NLRP3 inflammasome activation
Sign Up to like & getrecommendations! Published in 2023 at "Molecular Cancer Research"
DOI: 10.1158/1557-3125.ras23-a020
Abstract: Background: The importance of styryl benzyl sulfones that induce G2/M cell cycle arrest and apoptosis in tumor cells has raised interest in cancer therapeutics. Rigosertib (ON 01910.Na) has been characterized as a disruptor of multiple… read more here.
Keywords: ras mapk; cell; mapk signaling; rigosertib ... See more keywords