A model for RAS mutation patterns in cancers: finding the sweet spot
Sign Up to like & getrecommendations! Published in 2018 at "Nature Reviews Cancer"
DOI: 10.1038/s41568-018-0076-6
Abstract: The three RAS genes — HRAS, NRAS and KRAS — are collectively mutated in one-third of human cancers, where they act as prototypic oncogenes. Interestingly, there are rather distinct patterns to RAS mutations; the isoform… read more here.
Keywords: ras mutation; model ras; mutation patterns; sweet spot ... See more keywords
Infrequent RAS mutation is not associated with specific histological phenotype in gliomas
Sign Up to like & getrecommendations! Published in 2021 at "BMC Cancer"
DOI: 10.1186/s12885-021-08733-4
Abstract: Background Mutations in driver genes such as IDH and BRAF have been identified in gliomas. Meanwhile, dysregulations in the p53, RB1, and MAPK and/or PI3K pathways are involved in the molecular pathogenesis of glioblastoma. RAS… read more here.
Keywords: phenotype; specific histological; gliomas; ras mutation ... See more keywords
Analysis of RAS gene mutations in adverse events during first induction chemotherapy in childhood acute lymphoblastic leukemia
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DOI: 10.21037/tp-22-683
Abstract: Background The rat sarcoma virus (RAS) pathway controls cell proliferation, differentiation, and apoptosis, which have been implicated in the pathogenesis of various hematological malignancies. Prognostic importance of RAS gene mutation, relatively frequently in childhood acute… read more here.
Keywords: first induction; ras mutation; induction chemotherapy; mutation ... See more keywords
Prognostic Models Incorporating RAS Mutation to Predict Survival in Patients with Colorectal Liver Metastases: A Narrative Review
Sign Up to like & getrecommendations! Published in 2022 at "Cancers"
DOI: 10.3390/cancers14133223
Abstract: Recurrence and survival vary widely among patients who undergo curative-intent resection of colorectal liver metastases (CRLM). Prognostic models provide estimated probabilities of these outcomes and allow the effects of multiple potentially interacting variables to be… read more here.
Keywords: ras mutation; predict survival; prognostic models;