Impact of RAS mutations on the immune infiltrate of colorectal liver metastases: A preliminary study
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Leukocyte Biology"
DOI: 10.1002/jlb.5ab0220-608r
Abstract: Kirsten rat sarcoma viral oncogene homolog KRAS proto‐oncogene is the most common altered gene in colorectal cancer (CRC). Determining its mutational status, which is associated with worse prognosis and resistance to anti‐epidermal growth factor receptor… read more here.
Keywords: liver metastases; kras mutated; ras mutations; study ... See more keywords
Significance of RAS mutations in pulmonary metastases of patients with colorectal cancer
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Clinical Oncology"
DOI: 10.1007/s10147-019-01582-z
Abstract: RAS/BRAF mutations of colorectal cancer (CRC) play a crucial role in carcinogenesis and cancer progression and need to be considered for the therapeutic strategy choice. We used next-generation-sequencing (NGS) technology to assess RAS/BRAF mutation differences… read more here.
Keywords: colorectal cancer; ras mutations; pulmonary metastases; primary crc ... See more keywords
Emerging RAS, BRAF, and EGFR mutations in cell-free DNA of metastatic colorectal patients are associated with both primary and secondary resistance to first-line anti-EGFR therapy
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Clinical Oncology"
DOI: 10.1007/s10147-020-01691-0
Abstract: Oncogenic RAS mutations are negative biomarkers of response to epidermal growth factor receptor (EGFR) blockade. RAS mutations are usually detected in biopsies of primary colorectal tumors. However, the genomic profiles of primary tumors and metastases… read more here.
Keywords: egfr; secondary resistance; ras mutations; ras braf ... See more keywords
The role of circulating tumor cells and K-ras mutations in patients with locally advanced rectal cancer: a prospective study.
Sign Up to like & getrecommendations! Published in 2020 at "Molecular biology reports"
DOI: 10.1007/s11033-020-05973-8
Abstract: Rectal cancer is a common malignancy with a relatively poor prognosis. We assessed the possible prognostic and predictive role(s) of circulating tumor cells (CTCs) and K-ras mutations in locally advanced rectal carcinoma (LARC) patients. CTCs… read more here.
Keywords: rectal cancer; role circulating; ras mutations; circulating tumor ... See more keywords
Strategies to tackle RAS-mutated metastatic colorectal cancer
Sign Up to like & getrecommendations! Published in 2021 at "ESMO Open"
DOI: 10.1016/j.esmoop.2021.100156
Abstract: The RAS oncogene is among the most commonly mutated in cancer. RAS mutations are identified in about half of patients diagnosed with metastatic colorectal cancer (mCRC), conferring poor prognosis and lack of response to anti-epidermal… read more here.
Keywords: metastatic colorectal; mcrc; ras targeting; colorectal cancer ... See more keywords
Targeted data-independent acquisition for mass spectrometric detection of RAS mutations in formalin-fixed, paraffin-embedded tumor biopsies.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of proteomics"
DOI: 10.1016/j.jprot.2018.04.022
Abstract: Genomic testing for KRAS and NRAS mutations in clinical biopsies of various cancers is routinely performed to predict futility of anti-epidermal growth factor receptor (anti-EGFR) therapies. We hypothesized that RAS mutations could be detected and… read more here.
Keywords: data independent; ras mutations; mass; independent acquisition ... See more keywords
RAS mutations drive proliferative chronic myelomonocytic leukemia via a KMT2A-PLK1 axis
Sign Up to like & getrecommendations! Published in 2021 at "Nature Communications"
DOI: 10.1038/s41467-021-23186-w
Abstract: Proliferative chronic myelomonocytic leukemia (pCMML), an aggressive CMML subtype, is associated with dismal outcomes. RAS pathway mutations, mainly NRASG12D, define the pCMML phenotype as demonstrated by our exome sequencing, progenitor colony assays and a Vav-Cre-NrasG12D… read more here.
Keywords: plk1; ras mutations; chronic myelomonocytic; proliferative chronic ... See more keywords
Targeting RAS in pediatric cancer: is it becoming a reality?
Sign Up to like & getrecommendations! Published in 2019 at "Current Opinion in Pediatrics"
DOI: 10.1097/mop.0000000000000856
Abstract: PURPOSE OF REVIEW The current review aims to highlight the frequency of RAS mutations in pediatric leukemias and solid tumors and to propose strategies for targeting oncogenic RAS in pediatric cancers. RECENT FINDINGS The three… read more here.
Keywords: targeting ras; ras mutations; cancer; pediatric cancer ... See more keywords
Heterogeneity in RAS mutations: One size does not fit all
Sign Up to like & getrecommendations! Published in 2022 at "Science Signaling"
DOI: 10.1126/scisignal.adc9816
Abstract: Although oncogenic driver mutations in RAS occur in 20% of cancers, heterogeneity in the biologic outputs of different RAS mutants has hampered efforts to develop effective treatments for RAS-mutated cancers. In this issue of Science… read more here.
Keywords: heterogeneity; ras mutations; heterogeneity ras; mutations one ... See more keywords
Intratumorous heterogeneity for RAS mutations in a treatment-naïve colorectal tumour
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Clinical Pathology"
DOI: 10.1136/jclinpath-2017-204327
Abstract: Activating mutations in KRAS and NRAS genes in patients with colorectal cancer (CRC) are associated with a lack of response to treatment with anti-epidermal growth factor receptor (EGFR) therapies. Mutations in these genes are thought… read more here.
Keywords: treatment; ras mutations; intratumorous heterogeneity; colorectal tumour ... See more keywords
Abstract 710: Exosomal DNA has the potential to detect circulating tumor DNA in patients with colorectal cancer
Sign Up to like & getrecommendations! Published in 2020 at "Clinical Trials"
DOI: 10.1158/1538-7445.am2020-710
Abstract: [Introduction] Exosomes are small vesicles of endosomal origin, which are released by all cell types, and are involved in physiological and pathological processes including cancer progression and metastasis. Exosomes comprise proteins, lipids, and nucleic acids… read more here.
Keywords: dna; colorectal cancer; ras mutations; circulating tumor ... See more keywords