RAS nanoclusters are cell surface transducers that convert extracellular stimuli to intracellular signalling
Sign Up to like & getrecommendations! Published in 2023 at "FEBS Letters"
DOI: 10.1002/1873-3468.14569
Abstract: Mutations of rat sarcoma virus (RAS) oncogenes (HRAS, KRAS and NRAS) can contribute to the development of cancers and genetic disorders (RASopathies). The spatiotemporal organization of RAS is an important property that warrants further investigation.… read more here.
Keywords: stimuli intracellular; transducers convert; cell surface; extracellular stimuli ... See more keywords
RAS Nanoclusters Selectively Sort Distinct Lipid Headgroups and Acyl Chains
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Molecular Biosciences"
DOI: 10.3389/fmolb.2021.686338
Abstract: RAS proteins are lipid-anchored small GTPases that switch between the GTP-bound active and GDP-bound inactive states. RAS isoforms, including HRAS, NRAS and splice variants KRAS4A and KRAS4B, are some of the most frequently mutated proteins… read more here.
Keywords: ras proteins; pathology; biology; ras nanoclusters ... See more keywords