Equilibria between conformational states of the Ras oncogene protein revealed by high pressure crystallography
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DOI: 10.1039/d1sc05488k
Abstract: In this work, we experimentally investigate the allosteric transitions between conformational states on the Ras oncogene protein using high pressure crystallography. Ras protein is a small GTPase involved in central regulatory processes occurring in multiple… read more here.
Keywords: conformational states; pressure; ras oncogene; crystallography ... See more keywords
RAS oncogene signal strength regulates matrisomal gene expression and tumorigenicity of mouse keratinocytes.
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DOI: 10.1093/carcin/bgac083
Abstract: Environmental and molecular carcinogenesis are linked by the discovery that chemical carcinogen induced-mutations in the Hras or Kras genes drives tumor development in mouse skin. Importantly, enhanced expression or allele amplification of the mutant Ras… read more here.
Keywords: oncogene signal; ras oncogene; signal strength; expression ... See more keywords
Does Mutated K-RAS Oncogene Attenuate the Effect of Sulindac in Colon Cancer Chemoprevention?
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DOI: 10.1158/1940-6207.capr-17-0230
Abstract: The NSAID sulindac has been successfully used alone or in combination with other agents to suppress colon tumorigenesis in patients with genetic predisposition and also showed its efficacy in prevention of sporadic colon adenomas. At… read more here.
Keywords: sulindac; colon; ras oncogene; mutant ras ... See more keywords