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   Articles with "ras pathway" as a keyword



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Co‐mutation landscape and clinical significance of RAS pathway related gene mutations in patients with myelodysplastic syndrome

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recommendations! Published in 2022 at "Hematological Oncology"

DOI: 10.1002/hon.3099

Abstract: Single gene mutations in the RAS pathway are uncommon and of unknown significance in myelodysplastic syndrome (MDS) patients, RAS pathway‐related gene mutations (RASwaymut) as a whole may be significant and require further elucidation. The clinical… read more here.

Keywords: gene mutations; ras pathway; pathway related; mds patients ... See more keywords
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RTK-RAS pathway mutation is enriched in myeloid sarcoma

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recommendations! Published in 2018 at "Blood Cancer Journal"

DOI: 10.1038/s41408-018-0083-6

Abstract: Myeloid sarcoma (MS), or granulocytic sarcoma, is a rare extramedullary tumor of immature myeloid cells. MS may present simultaneously with or during the course of acute myeloid leukemia (AML), myelodysplastic syndrome (MDS), or any forms… read more here.

Keywords: sarcoma; myeloid sarcoma; rtk ras; cancer ... See more keywords
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microRNA-324-3p suppresses the aggressive ovarian cancer by targeting WNK2/RAS pathway

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recommendations! Published in 2022 at "Bioengineered"

DOI: 10.1080/21655979.2022.2056314

Abstract: ABSTRACT Ovarian cancer (OC) has the highest mortality rate among gynecological cancers, which progresses owing to dysregulated microRNAs (miRNAs) expression. Our study attempts to reveal the mechanism by which decreased miR-324-3p expression suppresses OC proliferation.… read more here.

Keywords: targeting wnk2; ras pathway; ovarian cancer; expression ... See more keywords

Phospholipase D1 promotes cervical cancer progression by activating the RAS pathway

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recommendations! Published in 2022 at "Journal of Cellular and Molecular Medicine"

DOI: 10.1111/jcmm.17439

Abstract: This study aimed to further investigate the effect of PLD1 on the biological characteristics of human cervical cancer (CC) cell line, CASKI and the potential related molecular mechanism. CRISPR/Cas9 genome editing technology was used to… read more here.

Keywords: caski cells; cervical cancer; activating ras; ras pathway ... See more keywords
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Abstract 1943: SHP2 inhibition as the backbone of targeted therapy combinations for the treatment of cancers driven by oncogenic mutations in the RAS pathway

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recommendations! Published in 2020 at "Cancer Research"

DOI: 10.1158/1538-7445.am2020-1943

Abstract: Direct targeting of oncogenic mutations in the RAS pathway, such as mutant EGFR, BRAFV600E, and most recently KRASG12C, has emerged as a beneficial therapeutic strategy for patients with cancers bearing these mutations. Mutant-selective inhibitors offer… read more here.

Keywords: shp2 inhibition; selective inhibitors; oncogenic mutations; mutations ras ... See more keywords

A Phase II Study of Azacitidine, Venetoclax, and Trametinib in Relapsed or Refractory Acute Myeloid Leukemia Harboring RAS Pathway-Activating Mutations

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recommendations! Published in 2022 at "Acta Haematologica"

DOI: 10.1159/000525566

Abstract: Introduction: RAS pathway mutations are common mechanisms of resistance to acute myeloid leukemia (AML) therapies. Trametinib, an oral MEK inhibitor, has been shown to have single-agent activity in relapsed/refractory AML and preclinical synergy with venetoclax.… read more here.

Keywords: venetoclax trametinib; ras pathway; relapsed refractory; azacitidine venetoclax ... See more keywords
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Frequency and Prognostic Significance of Recurrent Gene Mutations in Pediatric B-ALL: Report from the DFCI ALL Consortium

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recommendations! Published in 2020 at "Blood"

DOI: 10.1182/blood-2020-136190

Abstract: The application of next-generation sequencing (NGS) approaches to leukemia markedly expanded our understanding of the molecular landscape of pediatric acute lymphoblastic leukemia (ALL), but NGS integration into clinical care and therapeutic decision making is still… read more here.

Keywords: pathway mutations; frequency; dfci consortium; significance ... See more keywords

Molecular rationale for ERK and EGFR inhibition in colorectal cancer.

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recommendations! Published in 2018 at "Journal of Clinical Oncology"

DOI: 10.1200/jco.2018.36.4_suppl.679

Abstract: 679Background: Mutational activation of the RAS pathway occurs in >50% of human CRC tumors, and to date has been difficult to overcome. We recently identified receptor tyrosine phosphatase-S (PTPRS) as an important regulator of the… read more here.

Keywords: erk egfr; cell lines; crc; cancer ... See more keywords
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Reversibility and developmental neuropathology of linear nevus sebaceous syndrome caused by dysregulation of the RAS pathway.

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recommendations! Published in 2023 at "Cell reports"

DOI: 10.2139/ssrn.4132723

Abstract: Linear nevus sebaceous syndrome (LNSS) is a neurocutaneous disorder caused by somatic gain-of-function mutations in KRAS or HRAS. LNSS brains have neurodevelopmental defects, including cerebral defects and epilepsy; however, its pathological mechanism and potentials for… read more here.

Keywords: nevus sebaceous; linear nevus; sebaceous syndrome; ras pathway ... See more keywords

Integrins Cooperate With the EGFR/Ras Pathway to Preserve Epithelia Survival and Architecture in Development and Oncogenesis

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recommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"

DOI: 10.3389/fcell.2022.892691

Abstract: Adhesion to the extracellular matrix (ECM) is required for normal epithelial cell survival. Disruption of this interaction leads to a specific type of apoptosis known as anoikis. Yet, there are physiological and pathological situations in… read more here.

Keywords: egfr ras; cell; ras pathway; integrins cooperate ... See more keywords

Genomic Landscape of RTK/RAS Pathway and Tumor Immune Infiltration as Prognostic Indicator of Lung Adenocarcinoma

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recommendations! Published in 2022 at "Frontiers in Oncology"

DOI: 10.3389/fonc.2022.924239

Abstract: The RTK/RAS pathway is an oncogenic signaling pathway for which many targeted drugs have been developed; however, survival remains poor. A combination of targeted therapy and immunotherapy has emerged as an option for improving cancer… read more here.

Keywords: infiltration; lung adenocarcinoma; ras pathway; rtk ras ... See more keywords