Multivalent Small-Molecule Pan-RAS Inhibitors
Sign Up to like & getrecommendations! Published in 2017 at "Cell"
DOI: 10.1016/j.cell.2017.02.006
Abstract: Design of small molecules that disrupt protein-protein interactions, including the interaction of RAS proteins and their effectors, may provide chemical probes and therapeutic agents. We describe here the synthesis and testing of potential small-molecule pan-RAS ligands,… read more here.
Keywords: ras proteins; pan ras; small molecule; molecule pan ... See more keywords
SodC modulates ras and PKB signaling in Dictyostelium.
Sign Up to like & getrecommendations! Published in 2017 at "European journal of cell biology"
DOI: 10.1016/j.ejcb.2016.11.001
Abstract: We have previously reported that the basal RasG activity is aberrantly high in cells lacking Superoxide dismutase C (SodC). Here we report that other Ras proteins such as RasC and RasD activities are not affected… read more here.
Keywords: ras proteins; sodc cells; sodc; sodc modulates ... See more keywords
Insights into the Cross Talk between Effector and Allosteric Lobes of KRAS from Methyl Conformational Dynamics.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.2c00007
Abstract: KRAS is the most frequently mutated RAS protein in cancer patients, and it is estimated that about 20% of the cancer patients in the United States carried mutant RAS proteins. To accelerate therapeutic development, structures… read more here.
Keywords: allosteric lobes; lobes kras; conformational dynamics; ras proteins ... See more keywords
RAS, wanted dead or alive: Advances in targeting RAS mutant cancers
Sign Up to like & getrecommendations! Published in 2020 at "Science Signaling"
DOI: 10.1126/scisignal.aay6013
Abstract: New signaling insights level the playing field against the notoriously “undruggable” protein RAS. Oncogenic RAS proteins, which are mutated in approximately 24% of all human cancers, have earned a well-deserved reputation as being “undruggable.” However,… read more here.
Keywords: ras proteins; ras wanted; ras mutant; wanted dead ... See more keywords
Impaired Proteolysis of Noncanonical RAS Proteins Drives Clonal Hematopoietic Transformation
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Discovery"
DOI: 10.1158/2159-8290.cd-21-1631
Abstract: Loss-of-function alterations in LZTR1, a Cullin-3 RING E3 ubiquitin ligase adapter, and impaired ubiquitin-mediated degradation of RAS proteins via mutations in RIT1 drive clonal hematopoietic transformation. read more here.
Keywords: hematopoietic transformation; impaired proteolysis; ras proteins; proteolysis noncanonical ... See more keywords
RAS-MPAK Pathway Signaling in Health and Disease
Sign Up to like & getrecommendations! Published in 2018 at "Blood"
DOI: 10.1182/blood-2018-99-109378
Abstract: The p21ras (Ras) family of signal switch molecules is an essential component of proliferative responses to many extracellular stimuli including most hematopoietic growth factors and cytokines. Phosphorylation of tyrosine residues on activated cytokine/growth factor receptors… read more here.
Keywords: ras proteins; hyperactive ras; ras mutations; disease ... See more keywords
RAS Nanoclusters Selectively Sort Distinct Lipid Headgroups and Acyl Chains
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Molecular Biosciences"
DOI: 10.3389/fmolb.2021.686338
Abstract: RAS proteins are lipid-anchored small GTPases that switch between the GTP-bound active and GDP-bound inactive states. RAS isoforms, including HRAS, NRAS and splice variants KRAS4A and KRAS4B, are some of the most frequently mutated proteins… read more here.
Keywords: ras proteins; pathology; biology; ras nanoclusters ... See more keywords