Inhibition of intermittent calcium‐activated potassium channel (SK4) attenuates Ang II‐induced hypertrophy of human‐induced stem cell‐derived cardiomyocytes via targeting Ras–Raf–MEK1/2–ERK1/2 and CN–NFAT signaling pathways
Sign Up to like & getrecommendations! Published in 2022 at "Cell Biology International"
DOI: 10.1002/cbin.11948
Abstract: Cardiac hypertrophy caused by angiotensin II (Ang II) is essential for the pathological process of heart failure. The intermediate calcium‐activated potassium channel (SK4) has been shown to be involved in the process of the inflammatory… read more here.
Keywords: cell; hypertrophy; cardiac hypertrophy; calcium activated ... See more keywords
Isoprenylcysteine carboxyl methyltransferase is critical for glioblastoma growth and survival by activating Ras/Raf/Mek/Erk
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Chemotherapy and Pharmacology"
DOI: 10.1007/s00280-022-04401-x
Abstract: The poor outcomes in glioblastoma necessitate new therapeutic target. Isoprenylcysteine carboxyl methyltransferase (ICMT), a unique enzyme of the final step of prenylation that modifies activities of oncogenic proteins, represents a promising target for many cancers.… read more here.
Keywords: glioblastoma; ras raf; glioblastoma growth; mek erk ... See more keywords
Partners in Crime: Clandestine Operations among RAS-RAF Accomplices in Promoting Tumorigenesis.
Sign Up to like & getrecommendations! Published in 2019 at "Molecular cell"
DOI: 10.1016/j.molcel.2019.11.020
Abstract: In this issue of Molecular Cell, Terrell et al. (2019) characterize the interactions of RAS-RAF complexes in live cells. Using bioluminescence resonance energy transfer (BRET) technology, they show that individual RAF family members exhibit distinct binding… read more here.
Keywords: crime clandestine; among ras; clandestine operations; partners crime ... See more keywords
Promoted Skin Wound Healing by Tail-Amputated Eisenia foetida Proteins via the Ras/Raf/MEK/ERK Signaling Pathway
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DOI: 10.1021/acsomega.3c00317
Abstract: Skin wound healing is an important fundamental problem in biological and medical fields. This study aimed to investigate wound healing promotion of protein extract from tail-amputated Eisenia foetida (E. foetida) and reveal the mechanism correlated… read more here.
Keywords: raf mek; erk signaling; wound healing; tail amputated ... See more keywords
Long non-coding RNA SNHG16 regulates cell behaviors through miR-542-3p/HNF4α axis via RAS/RAF/MEK/ERK signaling pathway in pediatric neuroblastoma cells
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DOI: 10.1042/bsr20200723
Abstract: Abstract Neuroblastoma (NB) is an extracranial solid tumor in children with complex mechanism. Increasing reports indicated that long non-coding RNA (lncRNA) small nucleolar RNA host gene 16 (SNHG16) account for the pathogenesis of NB. Nevertheless,… read more here.
Keywords: 542 hnf4; mir 542; hnf4 axis; ras raf ... See more keywords
Biomarker analysis beyond angiogenesis: RAS/RAF mutation status, tumour sidedness, and second-line ramucirumab efficacy in patients with metastatic colorectal carcinoma from RAISE—a global phase III study
Sign Up to like & getrecommendations! Published in 2019 at "Annals of Oncology"
DOI: 10.1093/annonc/mdy461
Abstract: Abstract Background : Second-line treatment with ramucirumab+FOLFIRI improved overall survival (OS) versus placebo+FOLFIRI for patients with metastatic colorectal carcinoma (CRC) [hazard ratio (HR)=0.84, 95% CI 0.73–0.98, P = 0.022]. Post hoc analyses of RAISE patient data examined… read more here.
Keywords: mutation status; ramucirumab; ras raf; raf mutation ... See more keywords
LGG-44. A PHASE I DOSE ESCALATION TRIAL OF THE MEK1/2 INHIBITOR MEK162 (BINIMETINIB) IN CHILDREN WITH LOW-GRADE GLIOMAS AND OTHER RAS/RAF PATHWAY-ACTIVATED TUMORS
Sign Up to like & getrecommendations! Published in 2018 at "Neuro-oncology"
DOI: 10.1093/neuonc/noy059.385
Abstract: BACKGROUND Ras/Raf/MEK/ERK pathway activation is the primary driver of most pediatric low-grade gliomas (LGG). MEK162 is an orally bioavailable MEK1/2 inhibitor. read more here.
Keywords: grade gliomas; low grade; ras raf; mek1 inhibitor ... See more keywords
Inhibition of mutant RAS-RAF interaction by mimicking structural and dynamic properties of phosphorylated RAS
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DOI: 10.1101/2022.04.24.489309
Abstract: Undruggability of RAS proteins has necessitated alternative strategies for the development of effective inhibitors. In this respect, phosphorylation has recently come into prominence as this reversible post-translational modification attenuates sensitivity of RAS towards RAF. As… read more here.
Keywords: inhibition mutant; ras raf; mutant; mutant ras ... See more keywords
Mouse Hepatomas with Ha-ras and B-raf Mutations Differ in Mitogen-Activated Protein Kinase Signaling and Response to Constitutive Androstane Receptor Activation
Sign Up to like & getrecommendations! Published in 2018 at "Drug Metabolism and Disposition"
DOI: 10.1124/dmd.118.083014
Abstract: Nuclear receptors mediate the hepatic induction of drug-metabolizing enzymes by xenobiotics. Not much is known about enzyme induction in liver tumors. Here, we treated tumor-bearing mice with phenobarbital, an activator of the constitutive androstane receptor… read more here.
Keywords: androstane receptor; constitutive androstane; ras raf; activation ... See more keywords
Development of a High-throughput NanoBRET Screening Platform to Identify Modulators of the RAS/RAF Interaction
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DOI: 10.1158/1535-7163.mct-21-0175
Abstract: Activating mutations in RAS are found in approximately 30% of human cancers, resulting in the delivery of a persistent signal to critical downstream effectors that drive tumorigenesis. RAS-driven malignancies respond poorly to conventional cancer treatments… read more here.
Keywords: screening platform; platform identify; development; ras raf ... See more keywords
Abstract CT117: Synergism between inhibitors of the EGFR-RAS-RAF-MEK pathway and the WNT pathway
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-ct117
Abstract: Background Inhibitors of the EGFR-RAS-RAF-MEK (MAPK) pathway have been successfully developed to treat cancers. However, many patients do not benefit from these inhibitors due to primary or acquired resistance. In colorectal cancer (CRC), resistance to… read more here.
Keywords: inhibitor; wnt pathway; crc; ras raf ... See more keywords