The K-Ras, N-Ras, and H-Ras Isoforms: Unique Conformational Preferences and Implications for Targeting Oncogenic Mutants.
Sign Up to like & getrecommendations! Published in 2018 at "Cold Spring Harbor perspectives in medicine"
DOI: 10.1101/cshperspect.a031427
Abstract: Ras controls a multitude of cellular signaling processes, including cell proliferation, differentiation, and apoptosis. Deregulation of Ras cycling often promotes tumorigenesis and various other developmental disorders, termed RASopothies. Although the structure of Ras has been… read more here.
Keywords: preferences implications; conformational preferences; ras ras; isoforms unique ... See more keywords
RAS-MPAK Pathway Signaling in Health and Disease
Sign Up to like & getrecommendations! Published in 2018 at "Blood"
DOI: 10.1182/blood-2018-99-109378
Abstract: The p21ras (Ras) family of signal switch molecules is an essential component of proliferative responses to many extracellular stimuli including most hematopoietic growth factors and cytokines. Phosphorylation of tyrosine residues on activated cytokine/growth factor receptors… read more here.
Keywords: ras proteins; hyperactive ras; ras mutations; disease ... See more keywords