Autoantibodies targeting GPCRs and RAS-related molecules associate with COVID-19 severity
Sign Up to like & getrecommendations! Published in 2022 at "Nature Communications"
DOI: 10.1038/s41467-022-28905-5
Abstract: COVID-19 shares the feature of autoantibody production with systemic autoimmune diseases. In order to understand the role of these immune globulins in the pathogenesis of the disease, it is important to explore the autoantibody spectra.… read more here.
Keywords: molecules associate; ras related; related molecules; disease ... See more keywords
Decreased conformational stability in the oncogenic N92I mutant of Ras-related C3 botulinum toxin substrate 1
Sign Up to like & getrecommendations! Published in 2019 at "Science Advances"
DOI: 10.1126/sciadv.aax1595
Abstract: We demonstrate that the decrease in conformational stability underlies the oncogenic activity of the N92I mutant of Rac1. Ras-related C3 botulinum toxin substrate 1 (Rac1) functions as a molecular switch by cycling between an inactive… read more here.
Keywords: ras related; n92i mutant; mutant; conformational stability ... See more keywords
Overexpression of Ras-Related C3 Botulinum Toxin Substrate 2 Radiosensitizes Melanoma Cells In Vitro and In Vivo
Sign Up to like & getrecommendations! Published in 2019 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2019/5254798
Abstract: Radioresistance is the major obstacle in the radiotherapy of the malignant melanoma. Thus, it is of importance to increase the radiosensitivity of melanoma cells. In the present study, the radioresistant melanoma cell line OCM-1 with… read more here.
Keywords: melanoma cells; toxin substrate; ras related; related botulinum ... See more keywords
A Novel Ras--Related Signature Improves Prognostic Capacity in Oesophageal Squamous Cell Carcinoma
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2022.822966
Abstract: Oesophageal squamous cell carcinoma (ESCC) remains a clinically challenging disease with high morbidity rates and poor prognosis. ESCC is also the most common pathological type of oesophageal cancer (EC) in China. Ras-related genes are one… read more here.
Keywords: cell carcinoma; oesophageal squamous; squamous cell; ras related ... See more keywords
Ras-related protein Rab-20 inhibition alleviates cerebral ischemia/reperfusion injury by inhibiting mitochondrial fission and dysfunction
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Molecular Neuroscience"
DOI: 10.3389/fnmol.2022.986710
Abstract: Ras-related protein Rab-20 (Rab20) is induced in hypoxia and contributes to hypoxia-induced apoptosis. However, the role and mechanism of Rab20 in cerebral ischemia/reperfusion (I/R) injury need to be elucidated. We established a cerebral I/R injury… read more here.
Keywords: related protein; inhibition; ras related; rab20 ... See more keywords
Prediction of male fertility using Ras-related proteins
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Animal Science and Technology"
DOI: 10.5187/jast.2022.e83
Abstract: Abstract Identifying effective biomarkers for the diagnosis of male fertility is crucial for improving animal production and treating male infertility in humans. Ras-related proteins (Rab) are associated with morphological and motion kinematic functions in spermatozoa.… read more here.
Keywords: rab; male fertility; related proteins; ras related ... See more keywords