Analysis of patient-specific NF1 variants leads to functional insights for Ras signaling that can impact personalized medicine.
Sign Up to like & getrecommendations! Published in 2021 at "Human mutation"
DOI: 10.1002/humu.24290
Abstract: We have created a panel of twenty-nine NF1 variant cDNAs representing missense (MS) variants, many with clinically relevant phenotypes, in-frame deletions, splice variants, and nonsense (NS) variants. We have determined the functional consequences of the… read more here.
Keywords: ras activity; medicine; patient specific; analysis patient ... See more keywords
Targeting RAS signaling pathway as a potential therapeutic target in the treatment of colorectal cancer
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.25890
Abstract: The V‐Ki‐ras2 Kirsten rat sarcoma viral oncogene homolog (KRAS) is frequently dysregulated in colorectal cancer (CRC). It is involved in the modulation of several downstream effectors, that include: Raf/Mek/Erk, PI3K/Akt, RalGDS/p38MAPK, and Rac/Rho, and thereby… read more here.
Keywords: treatment; colorectal cancer; signaling pathway; targeting ras ... See more keywords
High-throughput screening identifies small molecules that bind to the RAS:SOS:RAS complex and perturb RAS signaling.
Sign Up to like & getrecommendations! Published in 2018 at "Analytical biochemistry"
DOI: 10.1016/j.ab.2018.01.025
Abstract: K-RAS is mutated in approximately 30% of human cancers, resulting in increased RAS signaling and tumor growth. Thus, RAS is a highly validated therapeutic target, especially in tumors of the pancreas, lung and colon. Although… read more here.
Keywords: nucleotide exchange; small molecules; ras signaling; molecules bind ... See more keywords
Kinase-mediated RAS signaling via membraneless cytoplasmic protein granules
Sign Up to like & getrecommendations! Published in 2021 at "Cell"
DOI: 10.1016/j.cell.2021.03.031
Abstract: Summary Receptor tyrosine kinase (RTK)-mediated activation of downstream effector pathways such as the RAS GTPase/MAP kinase (MAPK) signaling cascade is thought to occur exclusively from lipid membrane compartments in mammalian cells. Here, we uncover a… read more here.
Keywords: protein; protein granules; cytoplasmic protein; mapk signaling ... See more keywords
Oncogenic RAS Signaling Promotes Tumor Immunoresistance by Stabilizing PD-L1 mRNA
Sign Up to like & getrecommendations! Published in 2017 at "Immunity"
DOI: 10.1016/j.immuni.2017.11.016
Abstract: Summary The immunosuppressive protein PD‐L1 is upregulated in many cancers and contributes to evasion of the host immune system. The relative importance of the tumor microenvironment and cancer cell‐intrinsic signaling in the regulation of PD‐L1… read more here.
Keywords: ttp; expression; ras signaling; oncogenic ras ... See more keywords
Divergent effects of intrinsically active MEK variants on developmental Ras signaling
Sign Up to like & getrecommendations! Published in 2017 at "Nature Genetics"
DOI: 10.1038/ng.3780
Abstract: Germline mutations in Ras pathway components are associated with a large class of human developmental abnormalities, known as RASopathies, that are characterized by a range of structural and functional phenotypes, including cardiac defects and neurocognitive… read more here.
Keywords: mek variants; intrinsically active; divergent effects; active mek ... See more keywords
A dataset describing a suite of novel antibody reagents for the RAS signaling network
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Data"
DOI: 10.1038/s41597-019-0166-7
Abstract: RAS genes are frequently mutated in cancer and have for decades eluded effective therapeutic attack. The National Cancer Institute’s RAS Initiative has a focus on understanding pathways and discovering therapies for RAS-driven cancers. Part of… read more here.
Keywords: dataset describing; network; antibody; ras signaling ... See more keywords
BarH-like homeobox 2 represses the transcription of keratin 16 and affects Ras signaling pathway to suppress nasopharyngeal carcinoma progression
Sign Up to like & getrecommendations! Published in 2022 at "Bioengineered"
DOI: 10.1080/21655979.2022.2026549
Abstract: ABSTRACT Nasopharyngeal carcinoma (NPC) refers to a malignancy initiating from the superior mucosal epithelium of the nasopharynx. Optimal therapies for NPC are still needed. In this investigation, we attempted to explore whether BarH-like homeobox 2… read more here.
Keywords: like homeobox; nasopharyngeal carcinoma; signaling pathway; barh like ... See more keywords
THER-07. INHIBITION OF THE RAS SIGNALING ENHANCES VIRAL ONCOLYSIS IN MALIGNANT GLIOMAS
Sign Up to like & getrecommendations! Published in 2020 at "Neuro-Oncology"
DOI: 10.1093/neuonc/noaa222.857
Abstract: Abstract Pediatric malignant glioma indicates rapid proliferation, widely infiltrative properties and resistance to various therapies, and carries a very poor prognosis. There are methods of using virus within novel therapies under development against malignant neoplasms,… read more here.
Keywords: inhibition ras; vaccinia virus; ras signaling; stage ... See more keywords
Impairment of K‐Ras signaling networks and increased efficacy of epidermal growth factor receptor inhibitors by a novel synthetic miR‐143
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Science"
DOI: 10.1111/cas.13559
Abstract: Despite considerable research on K‐Ras inhibitors, none had been established until now. We synthesized nuclease‐resistant synthetic miR‐143 (miR‐143#12), which strongly silenced K‐Ras, its effector signal molecules AKT and ERK, and the K‐Ras activator Sos1. We… read more here.
Keywords: mir 143; mir; signaling networks; synthetic mir ... See more keywords
Abstract 4972: Novel Ras inhibitor DC070-547 potently and selectively blocks Ras-RBD binding, EGFR binding to Ras signaling complex, EGFR activation of Ras signaling, and growth of Ras-driven lung tumor cells
Sign Up to like & getrecommendations! Published in 2017 at "Cancer Research"
DOI: 10.1158/1538-7445.am2017-4972
Abstract: A novel series of compounds that potently and selectively inhibits the growth of tumor cells harboring constitutively activated Ras relative to cells lacking activated Ras were identified by screening a proprietary library of indene derivatives… read more here.
Keywords: egfr; dc070 547; tumor cells; ras signaling ... See more keywords