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Published in 2019 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2019.12.020
Abstract: Ras is a key member in the superfamily of small GTPase. Transforming between GTP-bound active state and GDP-bound inactive state in response to exogenous signals, Ras serves as a binary switch in various signaling pathways.…
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Keywords:
state;
pi3k;
ras4b;
activation pi3k ... See more keywords
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Published in 2020 at "Journal of Molecular Biology"
DOI: 10.1016/j.jmb.2020.01.002
Abstract: Abstract Ras recruits and activates effectors that transmit receptor-initiated signals. Monomeric Ras can bind Raf; however, Raf's activation requires dimerization, which can be facilitated by Ras dimerization. Previously, we showed that active K-Ras4B dimerizes in…
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Keywords:
kinase;
ras4b;
dimerization;
mitogen activated ... See more keywords
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Published in 2022 at "Journal of chemical information and modeling"
DOI: 10.1021/acs.jcim.2c00591
Abstract: K-Ras4B, the most frequently mutated Ras isoform in human tumors, plays a vital part in cell growth, differentiation, and survival. Its tail, the C-terminal hypervariable region (HVR), is involved in anchoring K-Ras4B at the cellular…
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Keywords:
state;
intrinsically disordered;
transition;
ras4b ... See more keywords
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2
Published in 2023 at "Iranian biomedical journal"
DOI: 10.52547/ibj.3857
Abstract: Background K-Ras mutations rarely occur in breast cancer. However, studies have supported that K-Ras upregulation is involved in breast cancer pathogenesis. Two main K-Ras transcript variants, K-Ras4A and K-Ras4B, arise originate from the alternative splicing…
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Keywords:
ductal carcinoma;
ras4a ras4b;
breast;
expression ... See more keywords