Insight into the mechanism of allosteric activation of PI3Kα by oncoprotein K-Ras4B.
Sign Up to like & getrecommendations! Published in 2019 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2019.12.020
Abstract: Ras is a key member in the superfamily of small GTPase. Transforming between GTP-bound active state and GDP-bound inactive state in response to exogenous signals, Ras serves as a binary switch in various signaling pathways.… read more here.
Keywords: state; pi3k; ras4b; activation pi3k ... See more keywords
Oncogenic K-Ras4B Dimerization Enhances Downstream Mitogen-activated Protein Kinase Signaling
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Molecular Biology"
DOI: 10.1016/j.jmb.2020.01.002
Abstract: Abstract Ras recruits and activates effectors that transmit receptor-initiated signals. Monomeric Ras can bind Raf; however, Raf's activation requires dimerization, which can be facilitated by Ras dimerization. Previously, we showed that active K-Ras4B dimerizes in… read more here.
Keywords: kinase; ras4b; dimerization; mitogen activated ... See more keywords
Markov State Models and Molecular Dynamics Simulations Reveal the Conformational Transition of the Intrinsically Disordered Hypervariable Region of K-Ras4B to the Ordered Conformation
Sign Up to like & getrecommendations! Published in 2022 at "Journal of chemical information and modeling"
DOI: 10.1021/acs.jcim.2c00591
Abstract: K-Ras4B, the most frequently mutated Ras isoform in human tumors, plays a vital part in cell growth, differentiation, and survival. Its tail, the C-terminal hypervariable region (HVR), is involved in anchoring K-Ras4B at the cellular… read more here.
Keywords: state; intrinsically disordered; transition; ras4b ... See more keywords
K-Ras4A Plays a More Significant Role than K-Ras4B in Ductal Carcinoma of Breast.
Sign Up to like & getrecommendations! Published in 2023 at "Iranian biomedical journal"
DOI: 10.52547/ibj.3857
Abstract: Background K-Ras mutations rarely occur in breast cancer. However, studies have supported that K-Ras upregulation is involved in breast cancer pathogenesis. Two main K-Ras transcript variants, K-Ras4A and K-Ras4B, arise originate from the alternative splicing… read more here.
Keywords: ductal carcinoma; ras4a ras4b; breast; expression ... See more keywords