RASA1 and NF1 are Preferentially Co-Mutated and Define A Distinct Genetic Subset of Smoking-Associated Non–Small Cell Lung Carcinomas Sensitive to MEK Inhibition
Sign Up to like & getrecommendations! Published in 2017 at "Clinical Cancer Research"
DOI: 10.1158/1078-0432.ccr-17-2343
Abstract: Purpose: Ras-GTPase–activating proteins (RasGAP), notably NF1 and RASA1, mediate negative control of the RAS/MAPK pathway. We evaluated clinical and molecular characteristics of non–small cell lung carcinoma (NSCLC) with RASA1 mutations in comparison with NF1-mutated cases.… read more here.
Keywords: rasa1 nf1; truncating mutations; rasa1; cancer ... See more keywords
EPHB4-RASA1-Mediated Negative Regulation of Ras-MAPK Signaling in the Vasculature: Implications for the Treatment of EPHB4- and RASA1-Related Vascular Anomalies in Humans
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DOI: 10.3390/ph16020165
Abstract: Ephrin receptors constitute a large family of receptor tyrosine kinases in mammals that through interaction with cell surface-anchored ephrin ligands regulate multiple different cellular responses in numerous cell types and tissues. In the cardiovascular system,… read more here.
Keywords: ras mapk; anomalies humans; vascular anomalies; rasa1 ... See more keywords
MicroRNA-21 regulates the biological behavior of esophageal squamous cell carcinoma by targeting RASA1
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DOI: 10.3892/or.2018.6944
Abstract: MicroRNA-21 (miR-21) has been revealed to play a crucial role in regulating the biological behavior, including proliferation, migration, invasion and metastasis in certain cancers. However, its role in esophageal squamous cell carcinoma (ESCC) has yet… read more here.
Keywords: esophageal squamous; mir; biological behavior; rasa1 ... See more keywords