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   Articles with "rasa3" as a keyword



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RASA3 is a candidate gene in sickle cell disease‐associated pulmonary hypertension and pulmonary arterial hypertension

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recommendations! Published in 2023 at "Pulmonary Circulation"

DOI: 10.1002/pul2.12227

Abstract: Abstract Pulmonary hypertension (PH) is associated with significant morbidity and mortality. RASA3 is a GTPase activating protein integral to angiogenesis and endothelial barrier function. In this study, we explore the association of RASA3 genetic variation… read more here.

Keywords: pulmonary hypertension; hypertension; expression; gene ... See more keywords
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RAS P21 Protein Activator 3 (RASA3) Specifically Promotes Pathogenic T Helper 17 Cell Generation by Repressing T‐Helper‐2‐Cell‐Biased Programs

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recommendations! Published in 2018 at "Immunity"

DOI: 10.1016/j.immuni.2018.09.004

Abstract: &NA; Pathogenic Th17 (pTh17) cells drive inflammation and immune‐pathology, but whether pTh17 cells are a Th17 cell subset whose generation is under specific molecular control remains unaddressed. We found that Ras p21 protein activator 3… read more here.

Keywords: pth17; rasa3; cell generation; pathology ... See more keywords
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RASA3 Is Essential for Early Mammalian Hematopoiesis and Modulates ERK Signaling in Terminal Erythropoiesis

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recommendations! Published in 2019 at "Blood"

DOI: 10.1182/blood-2019-130328

Abstract: The Ras GTPase-activating protein, RASA3, plays a critical non-redundant role in vertebrate erythropoiesis. The autosomal recessive scat mouse model carries a missense (G125V) mutation in Rasa3 that results in severe anemia, thrombocytopenia and leukopenia with… read more here.

Keywords: hematopoiesis; erythroid differentiation; rasa3; erk signaling ... See more keywords
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Increased Reactive Oxygen Species and Cell Cycle Defects Contribute to Anemia in the RASA3 Mutant Mouse Model scat

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recommendations! Published in 2018 at "Frontiers in Physiology"

DOI: 10.3389/fphys.2018.00689

Abstract: RASA3 is a Ras GTPase activating protein that plays a critical role in blood formation. The autosomal recessive mouse model scat (severe combined anemia and thrombocytopenia) carries a missense mutation in Rasa3. Homozygotes present with… read more here.

Keywords: anemia; rasa3; cell cycle; model ... See more keywords