Diffusion Magnetic Resonance Imaging Detects Progression in Parkinson's Disease: A Placebo‐Controlled Trial of Rasagiline
Sign Up to like & getrecommendations! Published in 2021 at "Movement Disorders"
DOI: 10.1002/mds.28838
Abstract: Rasagiline has received attention as a potential disease‐modifying therapy for Parkinson's disease (PD). Whether rasagiline is disease modifying remains in question. read more here.
Keywords: diffusion magnetic; magnetic resonance; disease; parkinson disease ... See more keywords
Long-term, open-label, phase 3 study of rasagiline in Japanese patients with early Parkinson’s disease
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DOI: 10.1007/s00702-018-1964-3
Abstract: Rasagiline is a monoamine oxidase B inhibitor with demonstrated efficacy and safety in patients with Parkinson’s disease (PD). We recently conducted the first randomized, double-blind, placebo-controlled trial of rasagiline in Japanese patients with early PD… read more here.
Keywords: patients early; placebo rasagiline; rasagiline; japanese patients ... See more keywords
Rasagiline, sleep quality and well-being in Parkinson’s disease: a pilot study
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DOI: 10.1007/s10072-022-06008-9
Abstract: Sleep disordersand excessive daytime sleepiness are among the commonest nonmotor symptoms in Parkinson disease (PD) and can contribute to significantly lower quality of life in affected patients. Various antiparkinson drugs exert a relevant influence on… read more here.
Keywords: pilot study; sleep quality; quality; parkinson disease ... See more keywords
One-step asymmetric synthesis of (R)- and (S)-rasagiline by reductive amination applying imine reductases
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DOI: 10.1039/c6gc03023h
Abstract: Imine reductases (IREDs) show great potential as catalysts for reductive amination of ketones to produce chiral secondary amines. In this work, we explored this potential and synthesized the pharmaceutically relevant (R)-rasagiline in high yields (up… read more here.
Keywords: rasagiline; imine reductases; reductive amination; one step ... See more keywords
Efficacy of rasagiline for the treatment of Parkinson’s disease: an updated meta-analysis
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DOI: 10.1080/07853890.2017.1293285
Abstract: Abstract Objective: Rasagiline is a second-generation potent selective inhibitor of monoamine oxidase-B. The aim of the study was to analyze the effectiveness of rasagiline in treatment of Parkinson’s disease (PD), both as monotherapy and combination… read more here.
Keywords: rasagiline; treatment; updrs scores; parkinson disease ... See more keywords
Rasagiline as Adjunct to Levodopa for Treatment of Parkinson's Disease: A Systematic Review and Meta-Analysis
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DOI: 10.1155/2022/4216452
Abstract: Background Rasagiline is a selective, irreversible monoamine oxidase type B inhibitor used as monotherapy in early Parkinson's disease and as an adjunct therapy to levodopa in Parkinson's disease with motor fluctuations. Objectives This meta-analysis aimed… read more here.
Keywords: rasagiline; motor; parkinson disease; levodopa ... See more keywords
Efficacy of rasagiline monotherapy for early Parkinson disease: A systematic review and meta-analysis of randomized controlled trials
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DOI: 10.1177/02698811221093795
Abstract: Background: Rasagiline monotherapy is approved in early Parkinson’s disease (PD) for motor benefit. However, the efficacy and optimal rasagiline dosage in improving Unified Parkinson’s Disease Rating Scale (UPDRS) subscale scores between Japanese and Caucasian individuals… read more here.
Keywords: rasagiline monotherapy; parkinson disease; rasagiline;
Curcumin modulation of L-dopa and rasagiline-induced neuroprotection in rotenone model of Parkinson’s disease
Sign Up to like & getrecommendations! Published in 2023 at "Iranian Journal of Basic Medical Sciences"
DOI: 10.22038/ijbms.2022.61687.13650
Abstract: Objective(s): Parkinson’s disease (PD) is one of the most incurable, chronic, and progressive neurodegenerative disorders Worldwide. Curcumin, a natural polyphenolic anti-oxidant compound, has a long history in traditional medicine. We investigate the effect of curcumin… read more here.
Keywords: curcumin; brain; rasagiline; motor ... See more keywords
Rasagiline Withdrawal Syndrome in Parkinson’s Disease
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DOI: 10.3390/brainsci12020219
Abstract: Parkinson’s disease (PD) patients using dopamine agonists can develop withdrawal symptoms, referred to as dopamine agonist withdrawal syndrome (DAWS), under dose tapering or discontinuation of these drugs. DAWS includes a severe stereotypical cluster of psychiatric… read more here.
Keywords: rasagiline; withdrawal; parkinson disease; withdrawal syndrome ... See more keywords