Design, synthesis and biological evaluation of rasagiline-clorgyline hybrids as novel dual inhibitors of monoamine oxidase-B and amyloid-β aggregation against Alzheimer's disease.
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DOI: 10.1016/j.ejmech.2020.112475
Abstract: A series of rasagiline-clorgyline hybrids was designed, synthesized and investigated in vitro for their inhibition of monoamine oxidase and amyloid-β aggregation. Most of compounds were found to be selective and highly potent hMAO-B inhibitors showing IC50… read more here.
Keywords: aggregation; clorgyline hybrids; monoamine oxidase; rasagiline clorgyline ... See more keywords