AB0053 ACTIVIN A AND FOLLISTATIN AFFECT THE INTERACTION OF ENDOTHELIAL CELLS AND RHEUMATOID ARTHRITIS SYNOVIAL FIBROBLASTS
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DOI: 10.1136/annrheumdis-2019-eular.4599
Abstract: Background: Activin A and its antagonist follistatin are part of an autoregulatory cycle, which is well known in the hypothalamic-pituitary-gonadal axis. Activins also have an important function in autoimmune diseases, such as rheumatoid arthritis (RA).… read more here.
Keywords: activin; follistatin; rasf; endothelial cells ... See more keywords
THU0042 EFFECT OF SPLEEN TYROSIN KINASE (SYK)-INHIBITORS ON RHEUMATOID ARTHRITIS SYNOVIAL FIBROBLASTS
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DOI: 10.1136/annrheumdis-2019-eular.4865
Abstract: Background: The spleen tyrosine kinase (syk) is an intracellular protein kinase involved in signal transmission processes of immune cells and non-hematopoietic cells, such as fibroblasts. Various syk-inhibitors are therefore currently being tested in preclinical and… read more here.
Keywords: tak 659; kinase; rasf; effect ... See more keywords
Additive Effects of VDBP and 1,25(OH)2D3 on the Viability and Apoptosis of Rheumatoid Arthritis Synovial Fibroblasts
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DOI: 10.3389/fendo.2020.583229
Abstract: Aim This study is to investigate the additive effect of Vitamin D-binding protein (VDBP) and 1,25(OH)2D3 on the viability and apoptosis of synovial cells from patients with rheumatoid arthritis (RA). Methods Synovial tissues and synovial… read more here.
Keywords: viability apoptosis; apoptosis; viability; rasf ... See more keywords
Targeting Activated Synovial Fibroblasts in Rheumatoid Arthritis by Peficitinib
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DOI: 10.3389/fimmu.2019.00541
Abstract: Background: Synovial fibroblasts (SF) play a major role in the pathogenesis of rheumatoid arthritis (RA) and develop an aggressive phenotype destroying cartilage and bone, thus termed RASF. JAK inhibitors have shown to be an efficient… read more here.
Keywords: rasf; rheumatoid arthritis; peficitinib; synovial fibroblasts ... See more keywords