Genetic disruption of N-RasG12D palmitoylation perturbs hematopoiesis and prevents myeloid transformation in mice.
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DOI: 10.1182/blood.2019003530
Abstract: Oncogenic RAS mutations pose substantial challenges for rational drug discovery. Sequence variations within the hypervariable region (HVR) of Ras isoforms underlie differential post-translational modification and subcellular trafficking, potentially resulting in selective vulnerabilities. Specifically, inhibiting the… read more here.
Keywords: palmitoylation; genetic disruption; mice; myeloid transformation ... See more keywords