Loss of MLL induces epigenetic dysregulation of Rasgrf1 to attenuate Kras-driven lung tumorigenesis.
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DOI: 10.1158/0008-5472.can-22-1475
Abstract: Menin is necessary for the formation of the menin/MLL complex and is recruited directly to chromatin. Menin is an important tumor suppressor in several cancer types, including lung cancer. Here, we investigated the role of… read more here.
Keywords: rasgrf1; menin; lung tumorigenesis; cancer ... See more keywords