RasGRP3 controls cell proliferation and migration in papillary thyroid cancer by regulating the Akt-MDM2 pathway.
Sign Up to like & getrecommendations! Published in 2017 at "Gene"
DOI: 10.1016/j.gene.2017.08.024
Abstract: Accumulating evidence has shown that Ras guanylnucleotide releasing peptide 3 (RasGRP3) is up-regulated in several distinct cancer types; however, its role in papillary thyroid cancer (PTC) remains unclear. In this study, we demonstrate that RasGRP3… read more here.
Keywords: proliferation migration; papillary thyroid; cell proliferation; thyroid cancer ... See more keywords
Mutant NPM1 maintains RASGRP3 protein stability via interaction with MID1 to promote acute myeloid leukemia cell proliferation and autophagy.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of leukocyte biology"
DOI: 10.1093/jleuko/qiad023
Abstract: BACKGROUND/OBJECTIVE Acute myeloid leukemia (AML) is a heterogeneous hematologic malignancy with high mortality in the world. NPM1 gene mutations are a frequent occurrence in AML leading to abnormal autophagy. While the mechanism of NPM1 mutation-driven… read more here.
Keywords: myeloid leukemia; cell proliferation; rasgrp3; acute myeloid ... See more keywords
Novel transduction of nutrient stress to Notch pathway by RasGRP3 promotes malignant aggressiveness in human esophageal squamous cell carcinoma.
Sign Up to like & getrecommendations! Published in 2017 at "Oncology reports"
DOI: 10.3892/or.2017.5996
Abstract: In the process of enlarging of tumors, the dissolving tissue structures and remodeling endothelial cells for restoring gas exchange and nutritional support, further facilitate tumor cell invasion and metastasis. Activation of Ras plays a critical… read more here.
Keywords: cell carcinoma; squamous cell; notch pathway; rasgrp3 ... See more keywords