Survey of tumorigenic sensitivity in 6-month rasH2-Tg mice studies compared with 2-year rodent assays
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DOI: 10.1293/tox.2021-0031
Abstract: The pharmacokinetic endpoint of a 25-fold increase in human exposure is one of the specified criteria for high-dose selection for 2-year carcinogenicity studies in rodents according to ICH S1C(R2). However, this criterion is not universally… read more here.
Keywords: rash2 mice; year; rodent; rash2 mouse ... See more keywords