Prevalence of NS5A resistance associated substitutions in patients with hepatitis C virus genotypes 1a and 3: Impact on current therapeutic strategies
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Medical Virology"
DOI: 10.1002/jmv.25048
Abstract: The presence of resistance‐associated substitutions (RASs) at NS5A region might compromise the efficacy of Direct Acting Antiviral agents (DAAs). HCV resistance at NS5A region is mainly focused on patients with hepatitis C virus (HCV) genotypes… read more here.
Keywords: g1a; rass; prevalence; associated substitutions ... See more keywords
Hepatitis C virus genotype 1 infection: Prevalence of NS5A and NS5B resistance‐associated substitutions in naïve patients from Argentina
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Medical Virology"
DOI: 10.1002/jmv.25536
Abstract: Direct acting antiviral (DAA) therapy against hepatitis C virus (HCV) increases sustained virologic response rates. Nevertheless, drug resistance has occasionally been associated with failure to DAA. However, the information about the prevalence of NS5A and… read more here.
Keywords: prevalence ns5a; ns5a ns5b; treatment; rass ... See more keywords
Prevalence of relevant NS5A resistance-associated substitutions to elbasvir in genotype 1a hepatitis C virus patients in Spain
Sign Up to like & getrecommendations! Published in 2018 at "Enfermedades Infecciosas Y Microbiologia Clinica"
DOI: 10.1016/j.eimce.2017.03.028
Abstract: Abstract Resistance-associated substitutions (RASs) to the new HCV NS5A inhibitor elbasvir may limit its efficacy and lead to virological failure in HCV-GT1a-infected patients. There are no data outside clinical trials evaluating their prevalence and impact… read more here.
Keywords: elbasvir; hcv; rass; prevalence ... See more keywords
The Risk Assessment for Sourcing Seafood (RASS): Empowering businesses to buy responsibly
Sign Up to like & getrecommendations! Published in 2017 at "Marine Policy"
DOI: 10.1016/j.marpol.2016.10.005
Abstract: Abstract The RASS web-based tool has been developed by the UK Sea Fish Industry Authority to inform UK seafood businesses and retailers about four environmental risks when sourcing wild-capture seafood; fish stock status, management efficacy,… read more here.
Keywords: risk assessment; rass; assessment sourcing; seafood ... See more keywords
Prevalence of Single and Multiple Natural NS3, NS5A and NS5B Resistance-Associated Substitutions in Hepatitis C Virus Genotypes 1–4 in Italy
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-26862-y
Abstract: Natural resistance-associated substitutions (RASs) are reported with highly variable prevalence across different HCV genotypes (GTs). Frequency of natural RASs in a large Italian real-life cohort of patients infected with the 4 main HCV-GTs was investigated.… read more here.
Keywords: ns3 ns5a; rass; prevalence; associated substitutions ... See more keywords
Development and validation of a RASS-related nomogram to predict the in-hospital mortality of neurocritical patients: a retrospective analysis based on the MIMIC-IV clinical database
Sign Up to like & getrecommendations! Published in 2022 at "Current Medical Research and Opinion"
DOI: 10.1080/03007995.2022.2113690
Abstract: Abstract Background Richmond agitation-sedation scale (RASS) is a simple and widely used tool for evaluating sedation and agitation in adult ICU patients. Early deep sedation has been shown to be an important independent predictor of… read more here.
Keywords: rass; mortality neurocritical; hospital mortality; neurocritical patients ... See more keywords
Hepatitis C Resistance-Associated Substitutions Among People Who Inject Drugs Treated With Direct-Acting Antiviral-Containing Regimens
Sign Up to like & getrecommendations! Published in 2021 at "Open Forum Infectious Diseases"
DOI: 10.1093/ofid/ofab474
Abstract: Abstract Background Resistance-associated substitutions (RASs) to HCV direct-acting antivirals (DAAs) can contribute to virologic failure and limit retreatment options. People who inject drugs (PWID) are at highest risk for transmission of resistant virus. We report… read more here.
Keywords: inject drugs; rass; direct acting; associated substitutions ... See more keywords
Crowdsourcing Based Cross Random Access Point Referencing for Video Coding
Sign Up to like & getrecommendations! Published in 2020 at "IEEE Signal Processing Letters"
DOI: 10.1109/lsp.2020.2983306
Abstract: In video coding, Random Access Points (RAPs) are inserted in a bitstream to support flexible tune-in but divide it into multiple independent Random Access Segments (RASs) that may have similar contents. To reduce redundancy between… read more here.
Keywords: random access; access; video coding; rass ... See more keywords
Hepatitis C virus early kinetics and resistance‐associated substitution dynamics during antiviral therapy with direct‐acting antivirals
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Viral Hepatitis"
DOI: 10.1111/jvh.12986
Abstract: The emergence of resistance‐associated substitutions (RASs) can compromise the high efficacy of direct‐acting antivirals (DAAs). Little is known about RASs selection at very early time points during DAA treatment. Therefore, we analyzed the potential emergence… read more here.
Keywords: direct acting; rass; resistance associated; acting antivirals ... See more keywords
Prevalence of HCV resistance‐associated substitutions among treatment‐failure patients receiving direct‐acting antiviral agents
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Viral Hepatitis"
DOI: 10.1111/jvh.13270
Abstract: Direct‐acting antiviral (DAA) failure, which is mainly associated with the selection of resistance‐associated substitutions (RASs), is not rare in HCV treatment. RAS data collected from published literature and RAS prevalence were integrated using meta‐analysis. DAA‐failure‐associated… read more here.
Keywords: failure patients; treatment; daa failure; rass ... See more keywords
Deep sedation predicts pressure injury in patients admitted to intensive care units.
Sign Up to like & getrecommendations! Published in 2022 at "Nursing in critical care"
DOI: 10.1111/nicc.12753
Abstract: BACKGROUND Patients in intensive care units (ICU) are frequently prescribed sedatives, which might increase the risk for pressure injury (PI). Although the association between sedation and incidence of PI has been noted, the adequate sedation… read more here.
Keywords: incidence; admitted icu; rass; patients admitted ... See more keywords