DNA methylation influences the CTCF‐modulated transcription of RASSF1A in lung cancer cells
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DOI: 10.1002/cbin.11868
Abstract: Ras‐association domain family 1A (RASSF1A) is one of the most methylated genes in lung cancer (LC). We investigate whether the high DNA methylation level of RASSF1A can relieve the resistance of RASSF1A to LC by… read more here.
Keywords: rassf1a; lung cancer; methylation; dna methylation ... See more keywords
RASSF1A inhibits epithelial–mesenchymal transition of gastric cancer cells by downregulating P‐JNK
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DOI: 10.1002/cbin.11958
Abstract: Gastric cancer (GC) is one of the most common gastrointestinal tumors. In this study, we assessed the biological role of Ras association domain family 1 isoform A (RASSF1A) in GC cells. Expressions of RASSF1A and… read more here.
Keywords: rassf1a; expression; jnk; gastric cancer ... See more keywords
Investigation of the relationship between CTLA4 and the tumor suppressor RASSF1A and the possible mediating role of STAT4 in a cohort of Egyptian patients infected with hepatitis C virus with and without hepatocellular carcinoma.
Sign Up to like & getrecommendations! Published in 2021 at "Archives of virology"
DOI: 10.1007/s00705-021-04981-8
Abstract: The Ras association domain family 1 isoform A (RASSF1A), cytotoxic T lymphocyte antigen 4 (CTLA-4), and signal transducer and activator of transcription 4 (STAT4) genes play a role in regulating the cell cycle, apoptosis, and… read more here.
Keywords: hepatocellular carcinoma; stat4; hcv mediated; hepatitis virus ... See more keywords
RASSF1A–Hippo pathway link in patients with urothelial carcinoma of bladder: plausible therapeutic target
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DOI: 10.1007/s11010-019-03648-y
Abstract: RASSF1A is a tumor suppressor gene, and its hypermethylation has been observed in cancers. RASSF1A acts as an upstream regulator of Hippo pathway and modulates its function. The aim of this study was to analyze… read more here.
Keywords: rassf1a; ctgf cyr61; rassf1a hippo; hippo pathway ... See more keywords
53BP1‐mediated recruitment of RASSF1A to ribosomal DNA breaks promotes local ATM signaling
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DOI: 10.15252/embr.202154483
Abstract: DNA lesions occur across the genome and constitute a threat to cell viability; however, damage at specific genomic loci has a relatively greater impact on overall genome stability. The ribosomal RNA gene repeats (rDNA) are… read more here.
Keywords: rassf1a; dna; local atm; atm signaling ... See more keywords
RASSF1A Enhances Chemosensitivity of NSCLC Cells Through Activating Autophagy by Regulating MAP1S to Inactivate Keap1-Nrf2 Pathway
Sign Up to like & getrecommendations! Published in 2021 at "Drug Design, Development and Therapy"
DOI: 10.2147/dddt.s269277
Abstract: Objective Cisplatin (DDP) is an effective first-line therapy for non-small cell lung cancer (NSCLC) treatment; however, it can cause resistance and thus pose an obstacle to the efficacy of chemotherapy in NSCLC. This study aims… read more here.
Keywords: autophagy; rassf1a; chemosensitivity; nrf2 pathway ... See more keywords
Identification of Cross Talk between FoxM1 and RASSF1A as a Therapeutic Target of Colon Cancer
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DOI: 10.3390/cancers11020199
Abstract: Metastatic colorectal cancer (mCRC) is characterized by the expression of cellular oncogenes, the loss of tumor suppressor gene function. Therefore, identifying integrated signaling between onco-suppressor genes may facilitate the development of effective therapy for mCRC.… read more here.
Keywords: rassf1a; colon cancer; expression; foxm1 rassf1a ... See more keywords
RASSF1A Suppresses Estrogen-Dependent Breast Cancer Cell Growth through Inhibition of the Yes-Associated Protein 1 (YAP1), Inhibition of the Forkhead Box Protein M1 (FOXM1), and Activation of Forkhead Box Transcription Factor 3A (FOXO3A)
Sign Up to like & getrecommendations! Published in 2020 at "Cancers"
DOI: 10.3390/cancers12092689
Abstract: Simple Summary The majority of breast cancers express the estrogen receptor alpha (ERα). This receptor is of central importance for breast cancer development and tumor outgrowth, and represents an important target for therapeutic intervention. However,… read more here.
Keywords: protein; breast; forkhead box; breast cancer ... See more keywords
Impact of Natural Compounds on DNA Methylation Levels of the Tumor Suppressor Gene RASSF1A in Cancer
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DOI: 10.3390/ijms18102160
Abstract: Epigenetic inactivation of tumor suppressor genes (TSG) is a fundamental event in the pathogenesis of human cancer. This silencing is accomplished by aberrant chromatin modifications including DNA hypermethylation of the gene promoter. One of the… read more here.
Keywords: rassf1a cancer; natural compounds; cancer; rassf1a ... See more keywords
RASSF1A methylation as a biomarker for detection of colorectal cancer and hepatocellular carcinoma
Sign Up to like & getrecommendations! Published in 2022 at "World Journal of Gastrointestinal Oncology"
DOI: 10.4251/wjgo.v14.i8.1574
Abstract: BACKGROUND Studies have validated the potential of methylated cell-free DNA as a biomarker in various tumors, and methylated DNA in plasma may be a potential biomarker for cancer. AIM To evaluate the diagnostic value of… read more here.
Keywords: rassf1a; methylation; dna; biomarker ... See more keywords