Non-cell-autonomous migration of RasV12-transformed cells towards the basal side of surrounding normal cells.
Sign Up to like & getrecommendations! Published in 2021 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2021.01.031
Abstract: Oncogenic transformation enables cells to behave differently from their neighboring normal cells. Both cancer and normal cells recognize each other, often promoting the extrusion of the former from the epithelial cell layer. Here, we show… read more here.
Keywords: normal cells; rasv12 transformed; towards basal; side surrounding ... See more keywords
Oncogenic Signaling Alters Cell Shape and Mechanics to Facilitate Cell Division under Confinement
Sign Up to like & getrecommendations! Published in 2020 at "Developmental Cell"
DOI: 10.1016/j.devcel.2020.01.004
Abstract: Summary To divide in a tissue, both normal and cancer cells become spherical and mechanically stiffen as they enter mitosis. We investigated the effect of oncogene activation on this process in normal epithelial cells. We… read more here.
Keywords: mechanics; confinement; oncogenic signaling; signaling alters ... See more keywords
ADAM-like Decysin-1 (ADAMDEC1) is a positive regulator of Epithelial Defense Against Cancer (EDAC) that promotes apical extrusion of RasV12-transformed cells
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-27469-z
Abstract: Recent studies have revealed that newly emerging transformed cells are often eliminated from epithelia via cell competition with the surrounding normal epithelial cells. However, it remains unknown whether and how soluble factors are involved in… read more here.
Keywords: transformed cells; adam like; apical extrusion; cancer ... See more keywords
Ha-RasV12-Induced Multilayer Cellular Aggregates Is Mediated by Rac1 Activation Rather Than YAP Activation
Sign Up to like & getrecommendations! Published in 2022 at "Biomedicines"
DOI: 10.3390/biomedicines10050977
Abstract: We demonstrate that Ha-RasV12 overexpression induces the nuclear translocation of Hippo effector Yes-associated protein (YAP) in MDCK cells via the hippo-independent pathway at the confluent stage. Ha-RasV12 overexpression leads to the downregulation of Caveolin-1 (Cav1)… read more here.
Keywords: junction integrity; rasv12; rasv12 induced; cellular aggregates ... See more keywords