Blockade of ASIC1a inhibits acid-induced rat articular chondrocyte senescence through regulation of autophagy.
Sign Up to like & getrecommendations! Published in 2022 at "Human cell"
DOI: 10.1007/s13577-022-00676-7
Abstract: Acid-sensitive ion channel 1a (ASIC1a), which is abundant in chondrocytes, can sense changes in extracellular acidification. Our previous data demonstrated that ASIC1a is involved in acid-induced rat articular chondrocyte damage in osteoarthritis; however, its specific… read more here.
Keywords: acid induced; senescence; rat articular; articular chondrocyte ... See more keywords
Necrostatin-1 ameliorates adjuvant arthritis rat articular chondrocyte injury via inhibiting ASIC1a-mediated necroptosis.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2018.09.031
Abstract: Necroptosis, a necrotic cell death pathway regulated by receptor interacting protein (RIP) 1 and 3, plays a key role in pathophysiological processes, including rheumatoid arthritis (RA). However, whether necroptosis is involved in RA articular cartilage… read more here.
Keywords: acid induced; rat articular; necroptosis; articular cartilage ... See more keywords