Intracerebral microdialysis coupled to LC-MS/MS for the determination tramadol and its major pharmacologically active metabolite O-desmethyltramadol in rat brain microdialysates.
Sign Up to like & getrecommendations! Published in 2017 at "Drug testing and analysis"
DOI: 10.1002/dta.2157
Abstract: A rapid and sensitive method involving liquid chromatography electrospray tandem mass spectrometry (LC-ESI-MS/MS) coupled to an intracerebral microdialysis technique was developed for the determination and pharmacokinetic investigation of tramadol and its major active metabolite O-desmethyltramadol… read more here.
Keywords: rat brain; microdialysis; intracerebral microdialysis; tramadol ... See more keywords
Towards the molecular origin of glutamate CEST (GluCEST) imaging in rat brain
Sign Up to like & getrecommendations! Published in 2019 at "Magnetic Resonance in Medicine"
DOI: 10.1002/mrm.28021
Abstract: Chemical exchange saturation transfer (CEST) signals at 3 ppm acquired with high irradiation powers, termed GluCEST, have been suggested as an indicator of glutamate in neural systems. However, amines in proteins may also contribute to… read more here.
Keywords: rat brain; cest; molecular origin; towards molecular ... See more keywords
Perfusion system for studying dynamic metabolomics in rat brain slices exposed to oxygen–glucose deprivation using proton and phosphorus nuclear magnetic resonance
Sign Up to like & getrecommendations! Published in 2022 at "NMR in Biomedicine"
DOI: 10.1002/nbm.4703
Abstract: The aim of the current study was to establish a controlled and reproducible model to study metabolic changes during oxygen–glucose deprivation (OGD) in rat brain using a nuclear magnetic resonance (NMR)‐compatible perfusion system. Rat brains… read more here.
Keywords: rat brain; brain slices; perfusion; perfusion system ... See more keywords
Purification of Clathrin-Coated Vesicles from Adult Rat Brain.
Sign Up to like & getrecommendations! Published in 2018 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-8719-1_1
Abstract: Here, we describe a purification protocol for isolating clathrin-coated vesicles (CCVs) from adult rat brain by using differential centrifugation coupled with Ficoll-sucrose and D2O-sucrose density gradient centrifugation and an additional linear sucrose step gradient at… read more here.
Keywords: adult rat; purification; clathrin coated; rat brain ... See more keywords
Desorption electrospray ionization (DESI) source coupling ion mobility mass spectrometry for imaging fluoropezil (DC20) distribution in rat brain
Sign Up to like & getrecommendations! Published in 2021 at "Analytical and Bioanalytical Chemistry"
DOI: 10.1007/s00216-021-03563-6
Abstract: Fluoropezil (DC20) is a new selective acetylcholinesterase inhibitor, and it was developed for the treatment of Alzheimer’s disease patients. In this study, a desorption electrospray ionization source coupling ion mobility mass spectrometry imaging (DESI/IMS-MSI) method… read more here.
Keywords: mass spectrometry; electrospray; ion mobility; rat brain ... See more keywords
Iron overload prevents oxidative damage to rat brain after chlorpromazine administration
Sign Up to like & getrecommendations! Published in 2018 at "BioMetals"
DOI: 10.1007/s10534-018-0104-8
Abstract: The hypothesis tested is that Fe administration leads to a response in rat brain modulating the effects of later oxidative challenges such as chlorpromazine (CPZ) administration. Either a single dose (acute Fe overload) or 6… read more here.
Keywords: rat brain; administration; overload; sub chronic ... See more keywords
Neuroanatomical distribution of galectin-3 in the adult rat brain
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Molecular Histology"
DOI: 10.1007/s10735-017-9712-9
Abstract: Galectin-3 is a member of the lectin subfamily that enables the specific binding of β-galactosides. It is expressed in a broad spectrum of species and organs, and is known to have various functions related to… read more here.
Keywords: rat brain; expression; distribution galectin; galectin ... See more keywords
Increase of mtDNA number and its mutant copies in rat brain after exposure to 150 MeV protons
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Biology Reports"
DOI: 10.1007/s11033-020-05491-7
Abstract: Proton beam therapy is widely used for treating brain tumor. Despite the efficacy of treatment, the use of this therapy has met some limitations associated with possible damage to normal brain tissues located beyond the… read more here.
Keywords: mutant copies; 150 mev; number; rat brain ... See more keywords
Glutamate-Weighted CEST Contrast After Removal of Magnetization Transfer Effect in Human Brain and Rat Brain with Tumor
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Imaging and Biology"
DOI: 10.1007/s11307-019-01465-9
Abstract: Purpose To mitigate the effect of magnetization transfer (MT) from glutamate-weighted chemical exchange saturation transfer (GluCEST) contrast in healthy human brain and its demonstration in a rat brain tumor model. Procedures GluCEST data was acquired… read more here.
Keywords: contrast; effect; brain tumor; rat brain ... See more keywords
Ascorbic acid protects male rat brain from oral potassium dichromate-induced oxdative DNA damage and apoptotic changes: the expression patterns of caspase-3, P 53, Bax, and Bcl-2 genes
Sign Up to like & getrecommendations! Published in 2018 at "Environmental Science and Pollution Research"
DOI: 10.1007/s11356-018-1546-9
Abstract: Our study designed to study the potential of potassium dichromate (K2Cr2O7) oral exposure to induce damage in male rat brain and to compare the possible protective role of vitamin C (VC) either pre and/or concurrent… read more here.
Keywords: supply; expression; damage; rat brain ... See more keywords
Comparative Analysis of the Expression of Chondroitin Sulfate Subtypes and Their Inhibitory Effect on Axonal Growth in the Embryonic, Adult, and Injured Rat Brains
Sign Up to like & getrecommendations! Published in 2020 at "Tissue Engineering and Regenerative Medicine"
DOI: 10.1007/s13770-020-00295-z
Abstract: Background: Chondroitin sulfate glycosaminoglycans (CS-GAGs) are the primary inhibitory GAGs for neuronal growth after central nervous system (CNS) injury. However, the inhibitory or permissive activity of CS-GAG subtypes is controversial and depends on the physiological… read more here.
Keywords: rat brain; adult; rat; axonal growth ... See more keywords