Hydrogen Sulfide Attenuates High Glucose-induced Myocardial Injury in Rat Cardiomyocytes by Suppressing Wnt/beta-catenin Pathway
Sign Up to like & getrecommendations! Published in 2019 at "Current Medical Science"
DOI: 10.1007/s11596-019-2120-5
Abstract: Diabetic cardiomyopathy (DCM) is one of the major heart complications of diabetic patients. Hydrogen sulfide (H2S) is now recognized as an important signaling molecule and has been shown to attenuate the development of diabetic cardiomyopathy.… read more here.
Keywords: high glucose; catenin pathway; rat cardiomyocytes; glucose induced ... See more keywords
Cytotoxicity of snake venom Lys49 PLA2-like myotoxin on rat cardiomyocytes ex vivo does not involve a direct action on the contractile apparatus
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-98594-5
Abstract: Viperid snake venoms contain a unique family of cytotoxic proteins, the Lys49 PLA2 homologs, which are devoid of enzymatic activity but disrupt the integrity of cell membranes. They are known to induce skeletal muscle damage… read more here.
Keywords: lys49 pla2; myotoxin; rat cardiomyocytes; snake venom ... See more keywords
Curcumin mitigates high glucose-induced cardiac oxidative stress via Notch1 pathway activation
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DOI: 10.1038/s41598-025-09105-9
Abstract: This study aims to investigate the protective effects of curcumin (CUR) in high glucose (HG)-induced oxidative stress and apoptosis of primary cardiomyocytes by activating the Notch1 signaling pathway. CUR is a natural polyphenol isolated from… read more here.
Keywords: high glucose; rat cardiomyocytes; stress; oxidative stress ... See more keywords
Reduction of myocardial ischaemia–reperfusion injury by inactivating oxidized phospholipids
Sign Up to like & getrecommendations! Published in 2019 at "Cardiovascular Research"
DOI: 10.1093/cvr/cvy136
Abstract: Aims Myocardial ischaemia followed by reperfusion (IR) causes an oxidative burst resulting in cellular dysfunction. Little is known about the impact of oxidative stress on cardiomyocyte lipids and their role in cardiac cell death. Our… read more here.
Keywords: death; myocardial ischaemia; infarct size; cell ... See more keywords
Modification of gene expression in rat cardiomyocytes by linoleic and docosahexaenoic acids 1.
Sign Up to like & getrecommendations! Published in 2019 at "Canadian journal of physiology and pharmacology"
DOI: 10.1139/cjpp-2018-0398
Abstract: Regulation of cardiac fatty acid metabolism is central to the development of cardiac hypertrophy and heart failure. We investigated the effects of select fatty acids on the expression of genes involved in immediate early as… read more here.
Keywords: genes involved; fatty acid; expression; acid ... See more keywords
Catestatin Induces Glucose Uptake and GLUT4 Trafficking in Adult Rat Cardiomyocytes
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DOI: 10.1155/2018/2086109
Abstract: Catestatin is a cationic and hydrophobic peptide derived from the enzymatic cleavage of the prohormone Chromogranin A. Initially identified as a potent endogenous nicotinic–cholinergic antagonist, Catestatin has recently been shown to act as a novel… read more here.
Keywords: glut4 trafficking; adult rat; catestatin; glucose uptake ... See more keywords
Impact of hyperbilirubinemia on rat cardiomyocyte injury
Sign Up to like & getrecommendations! Published in 2025 at "BMC Cardiovascular Disorders"
DOI: 10.1186/s12872-025-04859-6
Abstract: To investigate bilirubin-induced injury in rat myocardial cells at varying concentrations. The study utilized the rat cardiomyocyte cell line H9C2 and primary rat cardiomyocytes. Bilirubin-rich and control sera were prepared, and cells were cultured for… read more here.
Keywords: rat; rat cardiomyocyte; bilirubin induced; primary rat ... See more keywords
Sinapic Acid Inhibits Cardiac Hypertrophy via Activation of Mitochondrial Sirt3/SOD2 Signaling in Neonatal Rat Cardiomyocytes
Sign Up to like & getrecommendations! Published in 2020 at "Antioxidants"
DOI: 10.3390/antiox9111163
Abstract: Sinapic acid (SA) is a naturally occurring phenolic compound with antioxidant properties. It also has a wide range of pharmacological properties, such as anti-inflammatory, anticancer, and hepatoprotective properties. The present study aimed to evaluate the… read more here.
Keywords: cardiac hypertrophy; sinapic acid; hypertrophy; neonatal rat ... See more keywords
Trimethylamine N-Oxide Does Not Impact Viability, ROS Production, and Mitochondrial Membrane Potential of Adult Rat Cardiomyocytes
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms20123045
Abstract: Trimethylamine N-oxide (TMAO) is an organic compound derived from dietary choline and L-carnitine. It behaves as an osmolyte, a protein stabilizer, and an electron acceptor, showing different biological functions in different animals. Recent works point… read more here.
Keywords: adult rat; tmao; trimethylamine oxide; membrane potential ... See more keywords
Effects of Cobra Cardiotoxins on Intracellular Calcium and the Contracture of Rat Cardiomyocytes Depend on Their Structural Types
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24119259
Abstract: Cardiotoxins (CaTx) of the three-finger toxin family are one of the main components of cobra venoms. Depending on the structure of the N-terminal or the central polypeptide loop, they are classified into either group I… read more here.
Keywords: groups types; rat cardiomyocytes; different groups; group ... See more keywords
Attenuation of the upregulation of NF-κB and AP-1 DNA-binding activities induced by tunicamycin or hypoxia/reoxygenation in neonatal rat cardiomyocytes by SERCA2a overexpression
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Molecular Medicine"
DOI: 10.3892/ijmm.2021.4946
Abstract: The present study aimed to investigate the effects of the overexpression of sarco/endoplasmic reticulum Ca2+-ATPase (SERCA2a) on endoplasmic reticulum (ER) stress (ERS)-associated inflammation in neonatal rat cardiomyocytes (NRCMs) induced by tunicamycin (TM) or hypoxia/reoxygenation (H/R).… read more here.
Keywords: overexpression; serca2a; dna binding; overexpression serca2a ... See more keywords