MFN2 contributes to metabolic disorders and inflammation in the aging of rat chondrocytes and osteoarthritis.
Sign Up to like & getrecommendations! Published in 2020 at "Osteoarthritis and cartilage"
DOI: 10.1016/j.joca.2019.11.011
Abstract: OBJECTIVE Metabolic disorders and inflammation of chondrocytes are major pathological changes in aging cells and osteoarthritis (OA). Recent studies demonstrated age-related mitochondrial dysfunction may be a key contributing factor in the development of OA. Mitofusin… read more here.
Keywords: mfn2; mfn2 contributes; metabolic disorders; rat chondrocytes ... See more keywords
Echinacoside alleviates osteoarthritis in rats by activating the Nrf2-HO-1 signaling pathway
Sign Up to like & getrecommendations! Published in 2022 at "Immunopharmacology and Immunotoxicology"
DOI: 10.1080/08923973.2022.2088384
Abstract: Abstract Objective Osteoarthritis (OA) is a progressive disease characterized by degeneration of cartilage and echinacoside (Ech) has anti-inflammatory and antioxidant effects in various human diseases. This study aimed to reveal the effect and potential mechanism… read more here.
Keywords: rat chondrocytes; activating nrf2; signaling pathway; nrf2 signaling ... See more keywords
Tricetin Protects Rat Chondrocytes against IL-1β-Induced Inflammation and Apoptosis
Sign Up to like & getrecommendations! Published in 2019 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2019/4695381
Abstract: Tricetin is a well-studied flavonoid with a wide range of pharmacological activities in cancer and inflammation. However, the ability of tricetin to ameliorate the inflammation that occurs in osteoarthritis (OA) has not been determined. This… read more here.
Keywords: tricetin protects; inflammation; mmp; rat chondrocytes ... See more keywords
USP7 Inhibition Alleviates H2O2-Induced Injury in Chondrocytes via Inhibiting NOX4/NLRP3 Pathway
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DOI: 10.3389/fphar.2020.617270
Abstract: Osteoarthritis (OA), the most common form of arthritis, is a very common joint disease that often affects middle-aged to elderly people. However, current treatment options for OA are predominantly palliative. Thus, understanding its pathological process… read more here.
Keywords: inhibition; induced injury; h2o2 induced; usp7 ... See more keywords