S-Allylcysteine Protects Against Excitotoxic Damage in Rat Cortical Slices Via Reduction of Oxidative Damage, Activation of Nrf2/ARE Binding, and BDNF Preservation
Sign Up to like & getrecommendations! Published in 2020 at "Neurotoxicity Research"
DOI: 10.1007/s12640-020-00260-7
Abstract: Neuroprotective approaches comprising different mechanisms to counteract the noxious effects of excitotoxicity and oxidative stress need validation and detailed characterization. Although S-allylcysteine (SAC) is a natural compound exhibiting a broad spectrum of protective effects characterized… read more here.
Keywords: rat cortical; cortical slices; preservation; nrf2 binding ... See more keywords
Unbiased Proteomic Study of the Axons of Cultured Rat Cortical Neurons.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of proteome research"
DOI: 10.1021/acs.jproteome.8b00069
Abstract: The axon is a long projection connecting a neuron to its targets. Here, the axons of cultured rat cortical neurons were isolated with micropatterned chips that enable the separation of axons from their cell bodies.… read more here.
Keywords: rat cortical; unbiased proteomic; axons cultured; proteomic study ... See more keywords
Aging protects rat cortical slices against to oxygen-glucose deprivation induced damage
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Neuroscience"
DOI: 10.1080/00207454.2020.1730830
Abstract: Abstract Objective: In present study, we aimed to clarify effect of aging on the susceptibility of brain tissue to neurodegeneration induced by ischemia. Methods: Damage induced by oxygen-glucose deprivation (OGD) followed by reoxygenation (REO) were… read more here.
Keywords: slices oxygen; ogd reo; rat cortical; glucose deprivation ... See more keywords
Proteomic analysis of S-nitrosylated nuclear proteins in rat cortical neurons
Sign Up to like & getrecommendations! Published in 2018 at "Science Signaling"
DOI: 10.1126/scisignal.aar3396
Abstract: The S-nitrosylated proteome directs dendritogenesis in developing cortical neurons. Discovering the neuronal SNO-ome Posttranslational modifications (PTMs) regulate protein abundance, localization, and function. S-nitrosylation (or “SNO”) is a PTM involving the attachment of a nitric oxide… read more here.
Keywords: nitrosylated nuclear; rat cortical; nitrosylation; nuclear proteins ... See more keywords
Unconjugated bilirubin induces pyroptosis in cultured rat cortical astrocytes
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Neuroinflammation"
DOI: 10.1186/s12974-018-1064-1
Abstract: BackgroundBilirubin-induced neurological dysfunction (BIND), a severe complication of extreme neonatal hyperbilirubinemia, could develop into permanent neurodevelopmental impairments. Several studies have demonstrated that inflammation and nerve cell death play important roles in bilirubin-induced neurotoxicity; however, the… read more here.
Keywords: rat cortical; pyroptosis; unconjugated bilirubin; cortical astrocytes ... See more keywords
Thymosin β4 prevents oxygen-glucose deprivation/reperfusion-induced injury in rat cortical neurons
Sign Up to like & getrecommendations! Published in 2019 at "Neuropsychiatric Disease and Treatment"
DOI: 10.2147/ndt.s208600
Abstract: Purpose This study investigated whether thymosin (T) β4 protects against oxygen-glucose deprivation/reperfusion (OGD/R) injury in rat cortical neurons, as well as the underlying mechanisms. Methods Primary rat cortical neurons were transfected with Tβ4 overexpression plasmid;… read more here.
Keywords: cortical neurons; glucose deprivation; oxygen glucose; rat cortical ... See more keywords
The interplay of intracellular calcium and zinc ions in response to electric field stimulation in primary rat cortical neurons in vitro
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Cellular Neuroscience"
DOI: 10.3389/fncel.2023.1118335
Abstract: Recent pharmacological studies demonstrate a role for zinc (Zn2+) in shaping intracellular calcium (Ca2+) dynamics and vice versa in excitable cells including neurons and cardiomyocytes. Herein, we sought to examine the dynamic of intracellular release… read more here.
Keywords: rat cortical; ca2 zn2; intracellular calcium; primary rat ... See more keywords
Astrocytes enhance the tolerance of rat cortical neurons to glutamate excitotoxicity
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Medicine Reports"
DOI: 10.3892/mmr.2018.9799
Abstract: Glutamate excitotoxicity is responsible for neuronal death in acute neurological disorders, including stroke, trauma and neurodegenerative diseases. Astrocytes are the main cells for the removal of glutamate in the synaptic cleft and may affect the… read more here.
Keywords: rat cortical; neurons glutamate; absence astrocytes; cortical neurons ... See more keywords