Species specificity profiling of rat and human organic cation/carnitine transporter Slc22a5/SLC22A5 (Octn2/OCTN2).
Sign Up to like & getrecommendations! Published in 2017 at "Drug metabolism and pharmacokinetics"
DOI: 10.1016/j.dmpk.2016.08.005
Abstract: The purpose of this study was to characterize the uptake of carnitine, the physiological substrate, and the uptake of 3-(2,2,2-trimethylhydrazinium)propionate, a consensus substrate by rat Octn2 and human OCTN2 transporters as well as to characterize… read more here.
Keywords: slc22a5; octn2; rat human; carnitine ... See more keywords
Quantification of the Conjugated Forms of Dichlorobisphenol A (3,3'-Cl2BPA) in Rat and Human Plasma Using HPLC-MS/MS.
Sign Up to like & getrecommendations! Published in 2023 at "Therapeutic drug monitoring"
DOI: 10.1097/ftd.0000000000001074
Abstract: BACKGROUND Bisphenol A (BPA) is a ubiquitous contaminant that has endocrine-disrupting effects. Chlorinated derivatives of BPA are formed during chlorination of drinking water and have higher endocrine-disrupting activity. Dichlorobisphenol A (Cl2BPA) is the most abundant… read more here.
Keywords: dichlorobisphenol cl2bpa; quantification; rat human; conjugated forms ... See more keywords
In Vitro and In Vivo Metabolism of a Novel Antimitochondrial Cancer Metabolism Agent, CPI-613, in Rat and Human
Sign Up to like & getrecommendations! Published in 2022 at "Drug Metabolism and Disposition"
DOI: 10.1124/dmd.121.000726
Abstract: CPI-613, an inhibitor of pyruvate dehydrogenase (PDH) and α-ketoglutarate dehydrogenase (KGDH) enzymes, is currently in development for the treatment of pancreatic cancer, acute myeloid leukemia, and other cancers. CPI-613 is an analog of lipoic acid,… read more here.
Keywords: metabolism; oxidation; rat human; cpi 613 ... See more keywords
Application of the PET ligand [11C]ORM-13070 to examine receptor occupancy by the α2C-adrenoceptor antagonist ORM-12741: translational validation of target engagement in rat and human brain
Sign Up to like & getrecommendations! Published in 2020 at "EJNMMI Research"
DOI: 10.1186/s13550-020-00741-y
Abstract: Background Availability of the α 2C -adrenoceptor (α 2C -AR) positron emission tomography (PET) tracer, [ 11 C]ORM-13070, and the α 2C -AR antagonist ORM-12741 allows probing of the roles of this G-protein coupled receptor… read more here.
Keywords: orm 13070; rat human; human brain; orm 12741 ... See more keywords
Molecular and Functional Study of Transient Receptor Potential Vanilloid 1-4 at the Rat and Human Blood–Brain Barrier Reveals Interspecies Differences
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2020.578514
Abstract: Transient receptor potential vanilloid 1-4 (TRPV1-4) expression and functionality were investigated in brain microvessel endothelial cells (BMEC) forming the blood–brain barrier (BBB) from rat and human origins. In rat, Trpv1-4 were detected by qRT-PCR in… read more here.
Keywords: trpv1; expression; endothelial cells; rat human ... See more keywords
Evaluation of Herb–Drug Interaction Between Danshen and Rivaroxaban in Rat and Human Liver Microsomes
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.950525
Abstract: The combination of Salvia miltiorrhiza (Danshen) and rivaroxaban is a promising treatment option in clinical practice in China, but the herb–drug interaction between Danshen and rivaroxaban remains unclear. Therefore, this study aims to reveal the… read more here.
Keywords: rat human; danshen rivaroxaban; danshen; interaction danshen ... See more keywords
Localization of the Serotonin Transporter in the Dog Intestine and Comparison to the Rat and Human Intestines
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Veterinary Science"
DOI: 10.3389/fvets.2021.802479
Abstract: Serotonin is crucial in gastrointestinal functions, including motility, sensitivity, secretion, and the inflammatory response. The serotonin transporter (SERT), responsible for serotonin reuptake and signaling termination, plays a prominent role in gastrointestinal physiology, representing a promising… read more here.
Keywords: serotonin; rat human; human intestines; dog intestine ... See more keywords