Microwell-based pancreas-on-chip model enhances genes expression and functionality of rat islets of Langerhans
Sign Up to like & getrecommendations! Published in 2020 at "Molecular and Cellular Endocrinology"
DOI: 10.1016/j.mce.2020.110892
Abstract: Organ-on-chip technology is a promising tool for investigating physiological in vitro responses in drug screening development, and in advanced disease models. Within this framework, we investigated the behavior of rat islets of Langerhans in an… read more here.
Keywords: islets langerhans; chip model; rat islets; pancreas chip ... See more keywords
A Retrievable, Efficacious Polymeric Scaffold for Subcutaneous Transplantation of Rat Pancreatic Islets
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DOI: 10.1097/sla.0000000000001919
Abstract: Objective: We aim on developing a polymeric ectopic scaffold in a readily accessible site under the skin. Summary Background Data: The liver as transplantation site for pancreatic islets is associated with significant loss of islets.… read more here.
Keywords: islet; tissue; transplantation; pancreatic islets ... See more keywords
The Proliferative and Functional Roles of CEBP/A in Ins-1 832/13 Cells and Primary Rat Islets
Sign Up to like & getrecommendations! Published in 2023 at "Physiology"
DOI: 10.1152/physiol.2023.38.s1.5733656
Abstract: The beta cell transcription factor Nkx6.1, when overexpressed in primary rodent and human islets, is sufficient to enhance beta cell proliferation, increase insulin secretion and enhance cell survival. We have sought to define the transcriptional… read more here.
Keywords: cell; primary rat; 832 cells; ins 832 ... See more keywords
Berberine inhibits glucose oxidation and insulin secretion in rat islets.
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DOI: 10.1507/endocrj.ej17-0543
Abstract: Glucose promotes insulin secretion primarily via its metabolism and the production of metabolic coupling factors in beta-cells. The activation of AMP-activated protein kinase (AMPK), an energy sensor, results in a decrease in insulin secretion from… read more here.
Keywords: berberine; insulin secretion; secretion; rat islets ... See more keywords
Investigation of the Exometabolomic Profiles of Rat Islets of Langerhans Cultured in Microfluidic Biochip
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DOI: 10.3390/metabo12121270
Abstract: Diabetes mellitus (DM) is a complex disease with high prevalence of comorbidity and mortality. DM is predicted to reach more than 700 million people by 2045. In recent years, several advanced in vitro models and… read more here.
Keywords: investigation exometabolomic; exometabolomic profiles; biochip; islets langerhans ... See more keywords
Inhibition of TLR4 protects rat islets against lipopolysaccharide-induced dysfunction.
Sign Up to like & getrecommendations! Published in 2017 at "Molecular medicine reports"
DOI: 10.3892/mmr.2016.6097
Abstract: Oxidative stress leads to dysfunction in pancreatic cells, causing a reduction in insulin secretion following exposure to glucose. Toll-like receptor 4 (TLR4) may be activated by exposure to lipopolysaccharide (LPS) stress. TLR4 may mediate the initiation… read more here.
Keywords: dysfunction; inhibition tlr4; rat islets; tlr4 ... See more keywords