Spectrochemical determination of effects on rat liver of binary exposure to benzo[a]pyrene and 2,2′,4,4′‐tetrabromodiphenyl ether
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Applied Toxicology"
DOI: 10.1002/jat.4165
Abstract: Benzo[a]pyrene (B[a]P) and polybrominated diphenyl ethers (PBDEs) are persistent environmental contaminants. The effects in organisms of exposures to binary mixtures of such contaminants remain obscure. Attenuated total reflection Fourier‐transform infrared (ATR‐FTIR) spectroscopy is a label‐free,… read more here.
Keywords: tetrabromodiphenyl ether; binary exposure; exposure; benzo pyrene ... See more keywords
circRNA‐14723 promotes hepatocytes proliferation in rat liver regeneration by sponging rno‐miR‐16‐5p
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.29473
Abstract: Circular RNA (circRNA) is a subclass of noncoding RNA (ncRNA) detected within mammalian tissues and cells. However, its regulatory role during the proliferation phase of rat liver regeneration (LR) remains unreported. This study was designed… read more here.
Keywords: circ 14723; rno mir; proliferation; rat liver ... See more keywords
Mesenchyme-derived factors enhance preneoplastic growth by non-genotoxic carcinogens in rat liver
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DOI: 10.1007/s00204-017-2080-0
Abstract: Many frequently prescribed drugs are non-genotoxic carcinogens (NGC) in rodent liver. Their mode of action and health risks for humans remain to be elucidated. Here, we investigated the impact of two model NGC, the anti-epileptic… read more here.
Keywords: growth; non genotoxic; genotoxic carcinogens; rat liver ... See more keywords
Quantification of CYP2E1 in rat liver by UPLC-MS/MS-based targeted proteomics assay: a novel approach for enzyme activity assessment
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DOI: 10.1007/s00216-020-02757-8
Abstract: CYP2E1 is one of the most crucial isozymes of CYP450. It is responsible for metabolizing and activating a large number of toxicants and carcinogens, but the correlation between its abundance and activity has not been… read more here.
Keywords: cyp2e1; cyp2e1 rat; correlation; abundance ... See more keywords
Peroxisomes proliferation and pharmacological stimulation of autophagy in rat liver: evidence to support that autophagy may remove the “older” peroxisomes
Sign Up to like & getrecommendations! Published in 2017 at "Molecular and Cellular Biochemistry"
DOI: 10.1007/s11010-017-2979-z
Abstract: Like mitochondria, peroxisomes produce reactive oxygen species (ROS), compounds which have been implicated to play an important role in many degenerative diseases and aging itself, and an exaggerated ROS production might occur in altered or… read more here.
Keywords: older peroxisomes; evidence; autophagy; rat liver ... See more keywords
Hepatic glycerol metabolism is early reprogrammed in rat liver cancer development.
Sign Up to like & getrecommendations! Published in 2020 at "Biochimie"
DOI: 10.1016/j.biochi.2020.01.002
Abstract: Evidence shows that oral glycerol supplementation during the early stages of rat liver cancer reduces the growth of preneoplastic lesions. Besides, human hepatocellular carcinoma (HCC) cells display decreased expression of glycerol channel aquaporin 9 (AQP9)… read more here.
Keywords: glycerol metabolism; liver cancer; rat liver; glycerol ... See more keywords
Itaconic acid impairs the mitochondrial function by the inhibition of complexes II and IV and induction of the permeability transition pore opening in rat liver mitochondria.
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DOI: 10.1016/j.biochi.2020.07.011
Abstract: Itaconic acid (methylene-succinic acid, ItA) is an unsaturated dicarboxylic acid that is secreted by mammalian macrophages in response to a pro-inflammatory stimulus and shows an anti-inflammatory/antibacterial effect. Being a mitochondrial metabolite, it exhibits an inhibitory… read more here.
Keywords: liver mitochondria; effect; itaconic acid; rat liver ... See more keywords
Laminin-521 promotes quiescence in isolated stellate cells from rat liver.
Sign Up to like & getrecommendations! Published in 2018 at "Biomaterials"
DOI: 10.1016/j.biomaterials.2018.07.008
Abstract: The laminin α5 protein chain is an element of basement membranes and important to maintain stem cells. Hepatic stellate cells (HSC) are liver-resident mesenchymal stem cells, which reside in a quiescent state on a basement… read more here.
Keywords: laminin 521; hsc; rat liver; laminin ... See more keywords
Bendiocarb induced histopathological and biochemical alterations in rat liver and preventive role of vitamins C and E.
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DOI: 10.1016/j.etap.2016.11.018
Abstract: In this study, biochemical changes and histological structure of rat liver after bendiocarb administration and possible preventive effects of vitamins C and E were studied. The animals were given with bendiocarb, vitamin C and vitamin… read more here.
Keywords: alterations rat; biochemical alterations; bendiocarb induced; histopathological biochemical ... See more keywords
Mulberry crude extracts induce Nrf2 activation and expression of detoxifying enzymes in rat liver: Implication for its protection against NP-induced toxic effects
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DOI: 10.1016/j.jff.2017.03.024
Abstract: Abstract This study was to evaluate the detoxification ability of mulberry crude extract against NP-induced toxic effects in rats. The structures of the main active substances in mulberry crude extract were first identified by HPLC-Q-TOF-MS.… read more here.
Keywords: rat liver; toxic effects; crude extract; mulberry crude ... See more keywords
Stereostructure-activity mechanism of cyproconazole by cytochrome P450 in rat liver microsomes: A combined experimental and computational study.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of hazardous materials"
DOI: 10.1016/j.jhazmat.2021.125764
Abstract: Cyproconazole (CPZ), representing the chiral triazole fungicides, is widely used in the pharmaceutical and agricultural fields. To clarify its potential adverse effects on the generalized CYP-mediated processes within mammalian, a comparative experimental and computational approach… read more here.
Keywords: metabolism; rat liver; experimental computational; cpz ... See more keywords