Metabolic Hydrolysis of Aromatic Amides in Selected Rat, Minipig, and Human In Vitro Systems
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DOI: 10.1038/s41598-018-20464-4
Abstract: The release of aromatic amines from drugs and other xenobiotics resulting from the hydrolysis of metabolically labile amide bonds presents a safety risk through several mechanisms, including geno-, hepato- and nephrotoxicity. Whilst multiple in vitro… read more here.
Keywords: vitro systems; minipig human; hydrolysis; human vivo ... See more keywords